Trial reportAmerican journal of respiratory and critical care medicine2018
Long-Term Outcomes after Protocolized Sedation versus Usual Care in Ventilated Pediatric Patients.
Trial report in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00814099 (Sedation Management in Pediatric Patients With Acute Respiratory Failure), which is not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sedation Management in Pediatric Patients With Acute Respiratory Failure
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Risk factors of post-traumatic stress disorder after hospitalization in a pediatric intensive care unit: a systematic literature review.European child & adolescent psychiatry · 2024Pooled it
- Neurocognitive functioning and health-related quality of life of children after pediatric intensive care admission: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Pooled it
- Sedative Choice and Neurocognitive Outcomes After Critical Illness in Early Childhood.JAMA network open · 2026Trial
- School and Work Absences After Critical Care Hospitalization for Pediatric Acute Respiratory Failure: A Secondary Analysis of a Cluster Randomized Trial.JAMA network open · 2021Trial
- Income-driven socioeconomic status and presenting illness severity in children with acute respiratory failure.Research in nursing & health · 2021Trial
- Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control.The Journal of pediatrics · 2020Trial
- Roles and responsibilities of nurses in mechanical ventilation in pediatric intensive care units: a national survey in Austria.BMC nursing · 2026Article
- Article
- Protocolized sedation may reduce ventilation and sedation requirements in the pediatric intensive care unit: a systematic review and meta-analysis.Clinical and experimental pediatrics · 2025Article
- Infant feeding and criticality in children.Nursing in critical care · 2025Article
- Post-traumatic stress disorder in children after discharge from the pediatric intensive care unit: a scoping review.European child & adolescent psychiatry · 2025Article
- Association of inflammatory biomarkers with new functional morbidity at hospital discharge in children who survive severe sepsis.Frontiers in pediatrics · 2025Article
- Validation of the BioIntelliSense BioButton® device for physical activity monitoring in children and future application as a physical health outcome for critically Ill children.Frontiers in pediatrics · 2025Article
- Early predictors of unfavorable outcomes in pediatric acute respiratory failure.Journal of intensive care · 2024Article
- "I Didn't Realize How Hard It Was Going to Be Just Transitioning Back into Life": A Qualitative Exploration of Outcomes for Survivors of Pediatric Septic Shock.Journal of pediatric intensive care · 2024Article
- Design and rationale of the Post-Intensive Care Syndrome - paediatrics (PICS-p) Longitudinal Cohort Study.BMJ open · 2024Observational
- Outcomes of patients supported by mechanical ventilation and their families two months after discharge from pediatric intensive care unit.Frontiers in pediatrics · 2024Article
- Follow-up after PICU discharge for patients with acquired brain injury: the role of an abbreviated neuropsychological evaluation and a return-to-school program.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023Article
- Outcomes of Children Surviving Pediatric Acute Respiratory Distress Syndrome: From the Second Pediatric Acute Lung Injury Consensus Conference.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023Review
- Risk factors for health impairments in children after hospitalization for acute COVID-19 or MIS-C.Frontiers in pediatrics · 2023Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
rationaleWhether a nurse-implemented goal-directed sedation protocol resulting in more awake yet calm intubated children affects postdischarge functional status, health-related quality of life, or risk for post-traumatic stress disorder is unknown.
objectivesTo compare postdischarge outcomes in children with acute respiratory failure cluster-randomized to a sedation protocol or usual care.
methodsA stratified random sample of 1,360 patients from 31 centers in the RESTORE (Randomized Evaluation of Sedation Titration for Respiratory Failure) trial was assessed by mail, electronically, and/or telephone 6 months after ICU discharge. In treatment group comparisons, we controlled for age, baseline functional status, and severity of illness. MEASUREMENTS AND MAIN
resultsWe used the Pediatric Overall Performance Category and the Pediatric Cerebral Performance Category to characterize functional status, the Infant and Toddler Quality of Life Questionnaire (97-item full-length version) (<2 yr old) or Pediatric Quality of Life Inventory (≥2 yr old), and the Child Post-traumatic Stress Disorder Symptom Scale (≥8 yr old and developmentally able). Functional status worsened from baseline to follow-up in 20%. Decline in functional status did not differ by treatment arm and was more common among those with baseline impairment than those with baseline normal function (27 vs. 18%; P < 0.001). There were no significant differences in health-related quality of life total scores by treatment arm. Scores indicating risk of post-traumatic stress disorder occurred in 30%, with no difference between treatment arms.
conclusionsA sedation strategy that allows patients to be more awake and exposes them to fewer sedative and analgesic medications produces no long-term harm. However, postdischarge morbidity after acute respiratory failure is common. Clinical trial registered with www.clinicaltrials.gov (NCT00814099).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.