Evidence map›Paper›PMID 29313486›Full record

Trial reportThe American journal of tropical medicine and hygiene2018

Phase III Clinical Trial to Evaluate Ivermectin in the Reduction of

Sergio de Almeida Basano, Juliana de Souza Almeida Aranha Camargo, Gilberto Fontes, Antonieta Relvas Pereira, Jansen Fernandes Medeiros, Mayara Costa de Oliveira Laudisse, Ricardo de Godoi Mattos Ferreira, Luís Marcelo Aranha Camargo

Open access · greenAbstract readClinical Trial, Phase IIIRandomized Controlled Trial
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Broadening the range of use cases for ivermectin - a review of the evidence.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2022
    Review
  5. Mansonellosis, the most neglected human filariasis.New microbes and new infections · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sergio de Almeida BasanoUniversidade Federal de São João Del Rei, Campus Centro Oeste, Divinópolis, Brazil.
Juliana de Souza Almeida Aranha CamargoDepartamento de Medicina, Centro Universitário São Lucas, Porto Velho, Brazil.
Gilberto FontesInstituto Nacional de Epidemiologia na Amazônia Ocidental, Porto Velho, Brazil.
Antonieta Relvas PereiraUniversidade Federal de São João Del Rei, Campus Centro Oeste, Divinópolis, Brazil.
Jansen Fernandes MedeirosFiocruz-Rondônia, Fundação Oswaldo Cruz, Porto Velho, Brazil.
Mayara Costa de Oliveira LaudisseDepartamento de Medicina, Centro Universitário São Lucas, Porto Velho, Brazil.
Ricardo de Godoi Mattos FerreiraFiocruz-Rondônia, Fundação Oswaldo Cruz, Porto Velho, Brazil.
Luís Marcelo Aranha CamargoCentro de Pesquisas em Medicina Tropical de Rondônia/SESAU, Porto Velho, Brazil.
Federal University of São João del-Rei · BRCentro Universitário São Lucas · BRFundação Oswaldo Cruz · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of mansonelliasis is still a challenge because there are few clinical trials for the treatment of the disease. This double-blind, randomized, placebo-controlled study (phase III clinical trial) was conducted to evaluate the effectiveness of a single oral dose of ivermectin (0.15 mg/kg) in the reduction of the

Indexed as

Administration, OralAdolescentAdultAnimalsAnthelminticsBrazilDouble-Blind MethodDrug Administration ScheduleFemaleHumansIvermectinMaleMansonellaMansonelliasisMicrofilariaeMiddle AgedAnthelminticsIvermectin

Identifiers

PMID29313486
PMCPMC5930903
OpenAlexW2782928107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.