Evidence map›Paper›PMID 29313295›Full record

ArticleDrug delivery and translational research2018

Radiation preparation of L-arginine/acrylic acid hydrogel matrix patch for transdermal delivery of propranolol HCl in hypertensive rats.

Rasha R Radwan, Heba A Mohamed, H E Ali, Ghada A Mahmoud

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In one paragraph

Article in Drug delivery and translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rasha R RadwanNational Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo, Egypt. rasha_radwan33@yahoo.com.
Heba A MohamedNational Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo, Egypt.
H E AliNational Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo, Egypt.
Ghada A MahmoudNational Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo, Egypt.
Egyptian Atomic Energy Authority · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, L-arginine/acrylic acid (Arg/AAc) batch hydrogel was successfully prepared by gamma irradiation for transdermal delivery of propranolol HCl in hypertensive rats. The resulted system has been characterized by FTIR to confirm the hydrogel formation. The swelling behavior of the prepared hydrogels was investigated as a function of time and pH. The kinetics of swelling has been investigated. In vivo pharmacokinetics evaluation, skin irritation test, and histopathological studies were investigated. Furthermore, the antihypertensive efficacy of transdermal propranolol-loaded Arg/AAc hydrogel on methyl prednisolone acetate-induced hypertensive rats was evaluated. It was found that the prepared patches exhibited a sustained release of the drug into systemic circulation over oral route which is subjected to hepatic first-pass metabolism, coupled with a short plasma half-life. Transdermal administration displayed a prolonged antihypertensive effect in spontaneously hypertensive rats. Moreover, the skin irritation test and histopathological examination indicated that the prepared patches are not irritant and can be safely applied on the skin. These results indicated that the hydrogel system composed of Arg and AAc has potential as a transdermal delivery system.

Indexed as

AcrylatesAdministration, CutaneousAnimalsAntihypertensive AgentsArginineBlood PressureDrug LiberationFemaleGamma RaysHydrogelsHypertensionMethylprednisoloneMethylprednisolone AcetatePropranololRatsSkinAcrylatesacrylic acidAntihypertensive AgentsArginineHydrogelsMethylprednisoloneMethylprednisolone AcetatePropranololIn vitro studyIn vivo evaluationPropranolol HClRadiationTransdermal delivery

Identifiers

PMID29313295
OpenAlexW2782735937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.