ArticleJournal of pharmacokinetics and pharmacodynamics2018
Delayed logistic indirect response models: realization of oscillating behavior.
Article in Journal of pharmacokinetics and pharmacodynamics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Assessing accuracy of BiliPredics algorithm in predicting individual bilirubin progression in neonates-results from a prospective multi-center study.Frontiers in digital health · 2025Article
- Formulation and Validation of an Extended Sigmoid Emax Model in Pharmacodynamics.Pharmaceutical research · 2024Article
- Computing optimal drug dosing with OptiDose: implementation in NONMEM.Journal of pharmacokinetics and pharmacodynamics · 2023Article
- Leveraging Predictive Pharmacometrics-Based Algorithms to Enhance Perinatal Care-Application to Neonatal Jaundice.Frontiers in pharmacology · 2022Article
- Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions.Journal of pharmacokinetics and pharmacodynamics · 2021Review
- The rhythm of a preterm neonate's life: ultradian oscillations of heart rate, body temperature and sleep cycles.Journal of pharmacokinetics and pharmacodynamics · 2021Observational
- OptiDose: Computing the Individualized Optimal Drug Dosing Regimen Using Optimal Control.Journal of optimization theory and applications · 2021Article
- Pharmacometrics and Machine Learning Partner to Advance Clinical Data Analysis.Clinical pharmacology and therapeutics · 2020Article
- Indirect pharmacodynamic models for responses with circadian removal.Journal of pharmacokinetics and pharmacodynamics · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indirect response (IDR) models are probably the most frequently applied tools relating the effect of a signal to a baseline response. A response modeled by such a classical IDR model will always return monotonously to its baseline after drug administration. We extend IDR models with a delay process, i.e. a retarded response state, that leads to oscillating response behavior. First, IDR models with a first-order production and second-order loss term based on the famous logistic equation are constructed. Second, a delay process similar to the delayed logistic equation is included. Relations of the classical IDR model with our extended IDR model concerning response and model parameters are revealed. Simulations of typical response profiles are presented and data fitting of a model for leptin and cholesterol dynamics after administration of methylprednisolone is performed. The influence of the delay parameter on the other model parameters is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.