ArticleInflammopharmacology2018
Polar extract of Curcuma longa protects cartilage homeostasis: possible mechanism of action.
Article in Inflammopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Effect of turmeric products on knee osteoarthritis: a systematic review and network meta-analysis.BMC complementary medicine and therapies · 2025Pooled it
- Protective effects of turmerosaccharides rich extract ofFrontiers in veterinary science · 2026Article
- The comparison of curcuminoid formulations or its combination with conventional therapies versus conventional therapies alone for knee osteoarthritis.Clinical rheumatology · 2022Article
- Safety Evaluation of Standardized Extract ofBioMed research international · 2021Article
- Cartilage Homeostasis Affects Femoral Head Necrosis Induced by Methylprednisolone in Broilers.International journal of molecular sciences · 2020Article
- Evaluation of the articular cartilage in the knees of rats with induced arthritis treated with curcumin.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurcuma longa has been well documented for managing joint inflammation and pain. The present study investigated the effect of polar extract of C. longa (NR-INF-02) on cartilage homeostasis in human articular chondrocytes knee (NHAC-kn) cells to understand its plausible mechanism of action.
methodsDysregulation of cartilage homeostasis was induced by IL-1β and H
resultsNR-INF-02 significantly attenuated IL-1β-induced chondrocyte cytotoxicity, apoptosis and release of chondrocyte degradation markers such as IL-6, IL-8, COX-2, PGE
conclusionsNR-INF-02 protects cartilage homeostasis by maintaining the balance between synthesis and degradation of cartilage matrix.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.