Evidence map›Paper›PMID 29313165›Full record

ArticleTechniques in coloproctology2018

Effectiveness of sacral nerve stimulation in fecal incontinence after multimodal oncologic treatment for pelvic malignancies: a multicenter study with 2-year follow-up.

M Schiano di Visconte, G A Santoro, N Cracco, G Sarzo, G Bellio, M Brunner, Z Cui, K E Matzel

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Techniques in coloproctology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

M Schiano di VisconteColorectal and Pelvic Floor Diseases Center, Department of General Surgery, "S. Maria dei Battuti" Hospital, Via Brigata Bisagno, 4, 31015, Conegliano, TV, Italy. mschianodivisconte@gmail.com.
G A SantoroColorectal and Pelvic Floor Unit, Department of General Surgery, Treviso Regional Hospital, Treviso, Italy.
N CraccoDepartment of General Surgery, "Sacro Cuore Don Calabria" Hospital, Negrar, Verona, Italy.
G SarzoDepartment of General Surgery, "Sant'Antonio Hospital", Padua, Italy.
G BellioColorectal and Pelvic Floor Diseases Center, Department of General Surgery, "S. Maria dei Battuti" Hospital, Via Brigata Bisagno, 4, 31015, Conegliano, TV, Italy.
M BrunnerDepartment of Surgery, University Clinic, Erlangen, Germany.
Z CuiDepartment of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
K E MatzelDepartment of Surgery, University Clinic, Erlangen, Germany.
Ospedale di Santa Maria dei Battuti · ITCa' Foncello Hospital · ITOspedale Sacro Cuore Don Calabria · ITOspedale Sant Antonio · ITRenji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess whether sacral nerve stimulation (SNS) is an effective treatment for severe fecal incontinence (FI) after radiotherapy (RT)/chemoRT (CRT) in combination with pelvic surgery.

methodsA multicenter study was conducted on patients with FI that developed after multimodal therapy for pelvic tumors and was refractory to non-operative management, who were treated with SNS between November 2009 and November 2012. Data were prospectively collected and retrospectively analyzed. Cleveland Clinic FI score (CCFIS), FI episodes per week, FI Quality of Life (FIQoL), anorectal manometry and pudendal nerve terminal motor latency were evaluated before and after SNS.

resultsEleven patients (seven females, mean age 67.3 ± 4.8 years) were evaluated in the study period. Multimodal treatments included surgery and CRT (four rectal, two cervical and one prostate cancers), surgery and RT (one cervical and two endometrial cancers) and CRT (one anal cancer). The mean radiation dose was 5.3 Gy, and mean interval between the end of RT and onset of FI was 43.7 ± 23 months. Before SNS, the mean CCFIS and the mean number of FI episodes per week were 15.7 ± 2.8 and 12.3 ± 4.2, respectively. At 12-month follow-up, mean CCFIS improved to 3.6 ± 1.8 (p = 0.003) and the mean number of FI episodes decreased to 2.0 ± 1.9 per week (p = 0.003). These results persisted at 24-month follow-up. Significant improvement was also observed for each of the four domains of FIQoL at 12- and 24-month follow-up. Anorectal manometry values did not change significantly at follow-up.

conclusionsSNS is feasible and may be an effective therapeutic option for FI after multimodal treatment of pelvic malignancies.

Indexed as

AgedAntineoplastic ProtocolsCombined Modality TherapyFecal IncontinenceFemaleFollow-Up StudiesHumansLumbosacral PlexusMaleManometryMiddle AgedPelvic NeoplasmsProspective StudiesRectumRetrospective StudiesSacrumFecal incontinencePelvic chemoradiotherapyPelvic malignanciesSacral nerve stimulation

Identifiers

PMID29313165
OpenAlexW2782657136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.