Evidence map›Paper›PMID 29313136›Full record

ArticlePediatric nephrology (Berlin, Germany)2018

Klotho G-395A gene polymorphism: impact on progression of end-stage renal disease and development of cardiovascular complications in children on dialysis.

Eman A Elghoroury, Fatina I Fadel, Manal F Elshamaa, Dina Kandil, Doaa M Salah, Marwa M El-Sonbaty, Hebatallah Farouk, Mona Raafat, Soha Nasr

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Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  4. CYP24A1 and KL polymorphisms are associated with the extent of vascular calcification but do not improve prediction of cardiovascular events.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Eman A ElghorouryClinical & Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Fatina I FadelPediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Manal F ElshamaaPediatric Department, National Research Centre, Elbohous street, Cairo, Dokki, Postal code 12311, Egypt. manal_elshmaa@hotmail.com.
Dina KandilClinical & Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Doaa M SalahPediatric Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Marwa M El-SonbatyTaibah University, Al- Madinah Al- Munawwarah, Kingdom of Saudi Arabia.
Hebatallah FaroukClinical & Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Mona RaafatClinical & Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Soha NasrClinical & Chemical Pathology Department, National Research Centre, Cairo, Egypt.
National Research Centre · EGCairo University · EGTaibah University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKlotho G-395-A gene polymorphism may impact children with end-stage renal disease (ESRD). We investigated the relevance of Klotho G-395-A on ESRD development and progression, and its relationship with evolution of cardiovascular complications in pediatric dialysis patients.

methodsFifty-five children with chronic kidney disease (CKD) and seventy healthy children were genotyped for Klotho G-395A.

resultsIncidence of GA/AA genotypes and A allele were higher in ESRD patients compared with controls (54.5 vs. 7.1%, P < 0.001; 30.9 vs. 13.6%, P = 0.001, respectively). Also, children with GA/AA genotypes were 15.6 times more likely to develop ESRD than with GG genotype (95% CI 5.4-44.7, P < 0.001). A allele carriers have 2.8 times higher risk of developing ESRD than those with G allele (95% CI 1.5-5.35, P = 0.001). Also, the A allele could be considered a predictor of cardiovascular disease (CVD), as carriers have 161 times higher risk of cardiovascular complications than non-carriers (95% CI 21-1233, P < 0.001). All ESRD patients with CVD presented with left ventricular hypertrophy (LVH) and the frequency of A allele was significantly higher among ESRD children with LVH, whereas G allele frequency was significantly higher among ESRD children without LVH.

conclusionsThe A allele of the G-395A Klotho gene polymorphism shows a significantly higher frequency among children with CKD and those with CVD and LVH. This mutant allele could be used as a risk marker for the development of ESRD as well as a predictor of CVD in these children.

Indexed as

AdolescentAllelesCardiovascular DiseasesChildDisease ProgressionFemaleGenetic Predisposition to DiseaseGenotypeGlucuronidaseHumansKidney Failure, ChronicKlotho ProteinsMalePolymorphism, Single NucleotideGlucuronidaseKlotho ProteinsCardiovascular complicationsChildrenESRDGene polymorphismHemodialysisKlotho G-395AReal-time PCR

Identifiers

PMID29313136
OpenAlexW2783293553

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.