ArticleDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft2019
[RPE morphometry in geographic atrophy due to AMD].
Article in Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 4 citations in OpenAlex.
- Fundus autofluorescence imaging.Progress in retinal and eye research · 2021Review
- Association of Hyperautofluorescence Signals with Geographic Atrophy Progression in the METformin for the MINimization of Geographic Atrophy Progression Trial.Ophthalmology scienceArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
backgroundThe geographic atrophy (GA) junctional zone includes changes in retinal pigment epithelium (RPE) and Bruch's membrane complex that are still difficult to interpret even with clinical high-resolution imaging technologies. We measured and evaluated degenerative RPE cell changes in histological sections of GA eyes.
methodsIn this study seven GA eyes were evaluated by light microscopy. In three eye sections, zones of typical RPE alterations were graded (0 = normal; 1 = irregular cells but intact layer; 2 = rounded, enlarged, and/or heaped cells; 3 = migrating cells in retina; 4 = RPE absent). In each graded zone, we measured and analyzed A) the total height of the RPE cell layer, B) the height of individual RPE cells and C) the height of basal deposits.
resultsFrom the outer macula towards the central RPE atrophic area the RPE passed almost steadily upward through grades of increased pathology. A) Zone 2 exhibited highly variable total RPE height (16.9 ± 5.6 µm) with hypertrophic and heaped cells next to atrophic ones. In comparison, zone 0 and zone 1 showed less variability and a regular total RPE height (10.9 ± 2.6 µm). B) In zone 2 the size of altered RPE cells varied widely (12.4 ± 5.2 µm, min. 5.1, max. 27.5). All detected migrating RPE cells were hypertrophic. C) In zone 0 basal deposits were found sporadically. With progressing RPE alterations, basal deposits became progressively continuous and thicker and reached a considerable height at the atrophic zone (9.5 ± 4.3 µm).
conclusionOur measurements confirmed that degenerative RPE phenomena, particularly of degeneration grade 2/3 close to the actual RPE atrophy zone, are often large enough to be visualized in detail with already available modern imaging technologies (e. g. SD-OCT).
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