ArticleEuropean archives of psychiatry and clinical neuroscience2019
Neural correlates of instrumental responding in the context of alcohol-related cues index disorder severity and relapse risk.
Article in European archives of psychiatry and clinical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Learning Mechanisms in Alcohol Use Disorders.Addiction biology · 2026Review
- When cues take the wheel: cue-control across alcohol use disorder, binge-eating disorder, gambling disorder, and internet gaming disorder.Frontiers in psychology · 2026Review
- The Role of Pavlovian Bias in Smoking Cessation Success and Neurocognitive Alterations During Nicotine Withdrawal.bioRxiv : the preprint server for biology · 2025Article
- The Dopamine System in Mediating Alcohol Effects in Humans.Current topics in behavioral neurosciences · 2025Review
- Investigating approach/avoidance tendencies in male AUD patients through a gait initiation task: An exploratory posturography study.PloS one · 2025Article
- Elevated Amygdala Responses During De Novo Pavlovian Conditioning in Alcohol Use Disorder Are Associated With Pavlovian-to-Instrumental Transfer and Relapse Latency.Biological psychiatry global open science · 2023Article
- General Pavlovian-to-instrumental transfer in humans: Evidence from Bayesian inference.Frontiers in behavioral neuroscience · 2022Article
- Prior chronic alcohol exposure enhances Pavlovian-to-instrumental transfer.Alcohol (Fayetteville, N.Y.) · 2021Article
- Association of theJournal of psychopharmacology (Oxford, England) · 2021Article
- Development of a Classical Conditioning Task for Humans Examining Phasic Heart Rate Responses to Signaled Appetitive Stimuli: A Pilot Study.Frontiers in behavioral neuroscience · 2021Article
- Dissociating neural learning signals in human sign- and goal-trackers.Nature human behaviour · 2020Article
- An Adaptation of Pavlovian-to-Instrumental Transfer (PIT) Methodology to Examine the Energizing Effects of Reward-Predicting Cues on Behavior in Young Adults.Frontiers in psychology · 2020Article
- Evidence for incentive salience sensitization as a pathway to alcohol use disorder.Neuroscience and biobehavioral reviews · 2019Review
- Addiction as Learned Behavior Patterns.Journal of clinical medicine · 2019Review
- Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats.Frontiers in behavioral neuroscience · 2019Article
- Mild Effect of Nalmefene on Alcoholic Cue-Induced Response Invigoration in Alcohol Use Disorder Without Accompanying Changes in Electrophysiological Signatures of Early Visual Processing and Executive Control.Frontiers in pharmacology · 2019Article
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21 authors.
Funding
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Abstract
The influence of Pavlovian conditioned stimuli on ongoing behavior may contribute to explaining how alcohol cues stimulate drug seeking and intake. Using a Pavlovian-instrumental transfer task, we investigated the effects of alcohol-related cues on approach behavior (i.e., instrumental response behavior) and its neural correlates, and related both to the relapse after detoxification in alcohol-dependent patients. Thirty-one recently detoxified alcohol-dependent patients and 24 healthy controls underwent instrumental training, where approach or non-approach towards initially neutral stimuli was reinforced by monetary incentives. Approach behavior was tested during extinction with either alcohol-related or neutral stimuli (as Pavlovian cues) presented in the background during functional magnetic resonance imaging (fMRI). Patients were subsequently followed up for 6 months. We observed that alcohol-related background stimuli inhibited the approach behavior in detoxified alcohol-dependent patients (t = - 3.86, p < .001), but not in healthy controls (t = - 0.92, p = .36). This behavioral inhibition was associated with neural activation in the nucleus accumbens (NAcc) (t
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