Evidence map›Paper›PMID 29313099›Full record

ArticleInternational journal of legal medicine2018

Genetic variation and forensic characterization of highland Tibetan ethnicity reveled by autosomal STR markers.

Guanglin He, Zheng Wang, Yongdong Su, Xing Zou, Mengge Wang, Jing Liu, Yiping Hou

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Article in International journal of legal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

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9citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Guanglin HeInstitute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu, China.
Zheng WangInstitute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu, China.
Yongdong SuForensic Identification Center, Public Security Bureau of Tibet Autonomous Region, Lhasa, China.
Xing ZouDepartment of Forensic Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, China.
Mengge WangInstitute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu, China.
Jing LiuInstitute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu, China.
Yiping HouInstitute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu, China. profhou@yahoo.cn.

Funding

National Key R&D Program of China 2016YFC0800703National Natural Science Foundation of China No.81330073National Natural Science Foundation of China No.81571854
6 · The paper itself

Abstract

Understanding the origin and genetic background of Chinese high-altitude Tibetans play a pivotal role in medical genetics, archeology, anthropology, and forensics. In this study, to investigate the forensic characterization and genetic diversity of Chinese Tibetan, allele frequencies and corresponding forensic statistical parameters of 15 autosomal STRs included in the AmpFℓSTR® Sinofiler™ kit were obtained from 1220 Tibetan individuals residing in Lhasa country, Tibet Autonomous Region. We identified 191 alleles with corresponding allele frequencies varied from 0.0004 to 0.3984. The combined probability of discrimination and the combined probability of exclusion are 0.9999999999999999997 and 0.9999996, respectively. Our study provided the valuable dataset for forensic individual identification and parentage testing in the high-altitude Tibetan population. In addition, comprehensive population comparisons among 30 Chinese populations via PCA, AMOVA, MDS, and N-J tree demonstrated that the genetic components of Tibet Tibetan have received gene introgression from surrounding lowland populations (Such as Gansu Hui and Yunnan Bai) and Tibetan keeps the close genetic relationship with geographic neighboring populations.

Indexed as

Genetics, PopulationMicrosatellite RepeatsPolymorphism, GeneticDNA FingerprintingEthnicityGene FrequencyHumansPolymerase Chain ReactionPrincipal Component AnalysisTibetForensic geneticsGenetic polymorphismHighland TibetanShort tandem repeats

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.