ReviewBioengineering & translational medicine2016
Engineering responsive supramolecular biomaterials: Toward smart therapeutics.
Review in Bioengineering & translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Boosting cancer therapy with self-assembled inorganic nanocarriers via host-guest chemistry.Materials today. Bio · 2026Review
- Transiently amplified fluctuations assemble dissipative materials.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Competitive Inhibition as a Tool to Modulate and Predict Dynamic Hydrogel Mechanics.ACS central science · 2026Article
- Supramolecular nanotherapeutics based on cucurbiturils.Journal of nanobiotechnology · 2024Review
- Glucose-Triggered Gelation of Supramolecular Peptide Nanocoils with Glucose-Binding Motifs.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Controlled Bio-Orthogonal Catalysis Using Nanozyme-Protein Complexes via Modulation of Electrostatic Interactions.Materials (Basel, Switzerland) · 2024Article
- Crosslinking strategies for biomimetic hydrogels in bone tissue engineering.Biophysical reviews · 2023Review
- An Overview of Supramolecular Platforms Boosting Drug Delivery.Bioinorganic chemistry and applications · 2023Review
- Energy Landscapes of Supramolecular Peptide-Drug Conjugates Directed by Linker Selection and Drug Topology.ACS nano · 2022Article
- Fabrication of physical and chemical crosslinked hydrogels for bone tissue engineering.Bioactive materials · 2022Review
- Supramolecular biomaterials for bio-imaging and imaging-guided therapy.European journal of nuclear medicine and molecular imaging · 2022Review
- Tissue Engineering and Photodynamic Therapy: A New Frontier of Science for Clinical Application -An Up-To-Date Review.Frontiers in bioengineering and biotechnology · 2022Review
- (Macro)molecular self-assembly for hydrogel drug delivery.Advanced drug delivery reviews · 2021Review
- Cytotoxicity, Retention, and Anti-inflammatory Effects of a CeOACS pharmacology & translational science · 2021Article
- Nanotechnology Based Approaches in Phage Therapy: Overcoming the Pharmacological Barriers.Frontiers in pharmacology · 2021Review
- Strategies to Improve Nanofibrous Scaffolds for Vascular Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2020Review
- Assessing the range of enzymatic and oxidative tunability for biosensor design.Journal of materials chemistry. B · 2020Review
- Engineering the vasculature for islet transplantation.Acta biomaterialia · 2019Review
- Integrating Stimuli-Responsive Properties in Host-Guest Supramolecular Drug Delivery Systems.Theranostics · 2019Review
- Stimuli-Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine.Macromolecular bioscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Engineering materials using supramolecular principles enables generalizable and modular platforms that have tunable chemical, mechanical, and biological properties. Applying this bottom-up, molecular engineering-based approach to therapeutic design affords unmatched control of emergent properties and functionalities. In preparing responsive materials for biomedical applications, the dynamic character of typical supramolecular interactions facilitates systems that can more rapidly sense and respond to specific stimuli through a fundamental change in material properties or characteristics, as compared to cases where covalent bonds must be overcome. Several supramolecular motifs have been evaluated toward the preparation of "smart" materials capable of sensing and responding to stimuli. Triggers of interest in designing materials for therapeutic use include applied external fields, environmental changes, biological actuators, applied mechanical loading, and modulation of relative binding affinities. In addition, multistimuli-responsive routes can be realized that capture combinations of triggers for increased functionality. In sum, supramolecular engineering offers a highly functional strategy to prepare responsive materials. Future development and refinement of these approaches will improve precision in material formation and responsiveness, seek dynamic reciprocity in interactions with living biological systems, and improve spatiotemporal sensing of disease for better therapeutic deployment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.