ArticleAmerican journal of cancer research2017
MiR-491-5p negatively regulates cell proliferation and motility by targeting PDGFRA in prostate cancer.
Article in American journal of cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Knockdown of FOXD3-AS1 inhibits the progression of prostate cancer by targeting miR-491-5p/PEG10.Journal of cancer research and clinical oncology · 2025Article
- Long non-coding RNA OSTM1-AS1 promotes renal cell carcinoma progression by sponging miR-491-5p and upregulating MMP-9.Scientific reports · 2025Article
- Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer.World journal of gastrointestinal oncology · 2024Article
- LncRNA KCNQ1OT1 enhances the radioresistance of lung squamous cell carcinoma by targeting the miR-491-5p/TPX2-RNF2 axis.Journal of thoracic disease · 2022Article
- MicroRNA-363-3p, negatively regulated by long non-coding RNA small nucleolar RNA host gene 5, inhibits tumor progression by targeting Aurora kinase A in colorectal cancer.Bioengineered · 2022Article
- Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups.Current oncology (Toronto, Ont.) · 2021Article
- miR-491-5p inhibits the proliferation and migration of A549 cells by FOXP4.Experimental and therapeutic medicine · 2021Article
- EWI-2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis.Molecular oncology · 2021Article
- circ‑0000212 promotes cell proliferation of colorectal cancer by sponging miR‑491 and modulating FOXP4 expression.Molecular medicine reports · 2021Article
- miR-182 modulates cell proliferation and invasion in prostate cancer via targeting ST6GALNAC5.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- LncRNA MALAT1 Regulating Lung Carcinoma Progression via the miR-491-5p/UBE2C Axis.Pathology oncology research : POR · 2021Article
- MicroRNA‑491‑5p inhibits trophoblast cell migration and invasion through targeting matrix metalloproteinase‑9 in preeclampsia.Molecular medicine reports · 2020Article
- LncRNA VPS9D1-AS1 promotes cell proliferation in acute lymphoblastic leukemia through modulating GPX1 expression by miR-491-5p and miR-214-3p evasion.Bioscience reports · 2020Article
- Identifying the key genes and microRNAs in prostate cancer bone metastasis by bioinformatics analysis.FEBS open bio · 2020Article
- Oncogenic and tumor-suppressive microRNAs in prostate cancer.Current opinion in endocrine and metabolic research · 2020Article
- Hsa_circ_0001361 promotes bladder cancer invasion and metastasis through miR-491-5p/MMP9 axis.Oncogene · 2020Article
- Functional Analysis of the 3' Untranslated Region of the HumanNeuropsychiatric disease and treatment · 2020Article
- LncRNA SNHG8 promotes proliferation and invasion of gastric cancer cells by targeting the miR-491/PDGFRA axis.Human cell · 2020Article
- Clinical and biologic roles of PDGFRA in papillary thyroid cancer: a study based on immunohistochemical and in vitro analyses.International journal of clinical and experimental pathology · 2020Article
- Long non-coding RNA LBX2-AS1 enhances glioma proliferation through downregulating microRNA-491-5p.Cancer cell international · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNA-491-5p (miR-491-5p) has been implicated in several cancers; however, its role in human prostate cancer (PCa) remains unknown. In this study, we observed downregulation of miR-491-5p expression in PCa tissues and cell lines. CCK-8 and EdU assays showed that forced expression of miR-491-5p suppressed PCa cell proliferation, which was further confirmed in a cell cycle assay. Overexpression of miR-491-5p also reduced PCa cell migration and invasion abilities as indicated by Transwell assays. Additionally, miR-491-5p overexpression significantly inhibited PCa growth in a mouse xenograft model. Mechanistically, platelet-derived growth factor receptor α (PDGFRA) was found to be a novel target of miR-491-5p. Re-introduction of PDGFRA antagonized the inhibitory effects of miR-491-5p on the proliferation and motility abilities of PCa cells. In clinical samples of PCa, miR-491-5p was negatively correlated with PDGFRA expression, which was upregulated in PCa. Collectively, these results demonstrate that miR-491-5p acts as a tumor suppressor in PCa by directly targeting PDGFRA and may serve as a therapeutic biomarker for patients with PCa.
Indexed as
Identifiers
29312807PMC5752694W3022821448What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.