ArticleJournal of thoracic disease2017
Hemorrhage under veno-venous extracorporeal membrane oxygenation in acute respiratory distress syndrome patients: a retrospective data analysis.
Article in Journal of thoracic disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04268940 (Thrombo-Elastography Guided Management of ECMO), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Thrombo-Elastography Guided Management of ECMO
Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- The Novel Application of Surgiflo and Successful Hemostasis of Refractory Intrapulmonary Hemorrhage in Extracorporeal Membrane Oxygenation.Critical care explorations · 2025Article
- Analysis of non-physiological shear stress-induced red blood cell trauma across different clinical support conditions of the blood pump.Medical & biological engineering & computing · 2024Article
- Extracorporeal Membrane Oxygenation (ECMO)-Associated Coagulopathy in Adults.Diagnostics (Basel, Switzerland) · 2023Review
- Predictors associated with mortality of veno-venous extracorporeal membrane oxygenation therapy.Journal of thoracic disease · 2023Article
- Management of fulminating non-cardiogenic pulmonary edema following cardiac surgery.Journal of surgical case reports · 2023Article
- Venovenous Extracorporeal Membrane Oxygenation in Diffuse Alveolar Hemorrhage Secondary to Anti-neutrophil Cytoplasmic Autoantibody-associated Vasculitis: Starting without Systemic Anticoagulation.Internal medicine (Tokyo, Japan) · 2022Article
- Be Patient: Prolonged Extracorporeal Membrane Oxygenation Support Including Full System Switch With Favorable Outcome.Journal of medical cases · 2022Article
- Risk factors for bleeding complications during venovenous extracorporeal membrane oxygenation as a bridge to recovery.Artificial organs · 2022Article
- Heparin-free after 3000 IU heparin loaded in veno-venous ECMO supported acute respiratory failure patients with hemorrhage risk: a novel anti-coagulation strategy.Thrombosis journal · 2022Article
- Article
- Impact of Invasive Fungal Diseases on Survival under Veno-Venous Extracorporeal Membrane Oxygenation for ARDS.Journal of clinical medicine · 2022Article
- Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis.Intensive care medicine · 2022Article
- Six-Month Survival After Extracorporeal Membrane Oxygenation for Severe COVID-19.Journal of cardiothoracic and vascular anesthesia · 2021Observational
- Factor XIII Activity Might Already Be Impaired before Veno-Venous ECMO in ARDS Patients: A Prospective, Observational Single-Center Cohort Study.Journal of clinical medicine · 2021Article
- Secondary ARDS Following Acute Pancreatitis: Is Extracorporeal Membrane Oxygenation Feasible or Futile?Journal of clinical medicine · 2021Article
- Anticoagulation Management in Severe Coronavirus Disease 2019 Patients on Extracorporeal Membrane Oxygenation.Journal of cardiothoracic and vascular anesthesia · 2021Observational
- Extracorporeal membrane oxygenation without systemic anticoagulation: a case-series in challenging conditions.Journal of thoracic disease · 2020Article
- Post-cardiotomy venovenous extracorporeal membrane oxygenation without heparinization.General thoracic and cardiovascular surgery · 2019Article
- Platelet Function During Extracorporeal Membrane Oxygenation in Adult Patients.Frontiers in cardiovascular medicine · 2019Article
- Principles and indications of extracorporeal life support in general thoracic surgery.Journal of thoracic disease · 2018Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite being still invasive and challenging, technical improvement has resulted in broader and more frequent application of extracorporeal membrane oxygenation (ECMO), to prevent hypoxemia and to reduce invasiveness of mechanical ventilation (MV). Heparin-coated ECMO-circuits are currently standard of care, in addition to heparin based anticoagulation (AC) regimen guided by activated clotting time (ACT) or activated partial thromboplastin time (aPTT). Despite these advances, a reliable prediction of hemorrhage is difficult and the risk of hemorrhagic complication remains unfortunately high. We hypothesized, that there are coagulation parameters that are indices for a higher risk of hemorrhage under veno-venous (VV)-ECMO therapy.
methodsData from 36 patients with severe respiratory failure treated with VV-ECMO at a University Hospital intensive care unit (ICU) were analyzed retrospectively. Patients were separated into two groups based on severity of hemorrhagic complications and transfusion requirements. The following data were collected: demographics, hemodynamic data, coagulation samples, transfusion requirements, change of ECMO-circuit during treatment and adverse effects, including hemorrhage and thrombosis.
resultsIn this study 74 hemorrhagic events were observed, one third of which were severe. Patients suffering from severe hemorrhage had a lower survival rate on VV-ECMO (43%
conclusionsSevere hemorrhage under VV-ECMO is associated with higher mortality. Only factor VII and X differed between groups. Further clinical studies are required to determine the timing of initiation and targets for AC therapies during VV-ECMO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.