Evidence map›Paper›PMID 29312600›Full record

ArticleOncotarget2017

Mild hypothermia modulates the expression of nestin and caspase-3 in the sub-granular zone and improves neurological outcomes in rats with ischemic stroke.

Dan Yu, Xueying Wang, Feng Zhou, Liang Wang, Guoshuai Yang, Wei Zhong, Ying Li, Zhiping Zhou, Aiyue Wang, Yanhui Zhou

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dan YuDepartment of Neurology, Haikou Municipal Hospital, Xiangya Medical College, Central South University, Haikou 570208, Hainan, P. R. China.
Xueying WangDepartment of Neurology, Affiliated Hospital, Chifeng College, Chifeng 024005, Inner Mongolia, P. R. China.
Feng ZhouDepartment of Neurology, Haikou Municipal Hospital, Xiangya Medical College, Central South University, Haikou 570208, Hainan, P. R. China.
Liang WangDepartment of Neurology, Haikou Municipal Hospital, Xiangya Medical College, Central South University, Haikou 570208, Hainan, P. R. China.
Guoshuai YangDepartment of Neurology, Haikou Municipal Hospital, Xiangya Medical College, Central South University, Haikou 570208, Hainan, P. R. China.
Wei ZhongDepartment of Neurology, Haikou Municipal Hospital, Xiangya Medical College, Central South University, Haikou 570208, Hainan, P. R. China.
Ying LiDepartment of Neurology, Haikou Municipal Hospital, Xiangya Medical College, Central South University, Haikou 570208, Hainan, P. R. China.
Zhiping ZhouDepartment of Neurology, Haikou Municipal Hospital, Xiangya Medical College, Central South University, Haikou 570208, Hainan, P. R. China.
Aiyue WangDepartment of Neurology, Haikou Municipal Hospital, Xiangya Medical College, Central South University, Haikou 570208, Hainan, P. R. China.
Yanhui ZhouDepartment of Neurology, Haikou Municipal Hospital, Xiangya Medical College, Central South University, Haikou 570208, Hainan, P. R. China.
Central South University · CNChifeng University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We assessed neurological outcomes, infarct volume, and the expression of nestin and caspase-3 in the hippocampal dentate gyrus following middle cerebral artery occlusion (MCAO) followed by reperfusion, with mild hypothermia (MH) treatment at the onset of ischemia in a MCAO rat model. Reperfusion began 2 hours after the MCAO model was set-up. MH treatment began at the onset of ischemia and was maintained for 4 hours. We evaluated neurological deficit score, brain infarct volumes, along with the immunohistochemical staining of nestin and caspase-3 in the sub-granular zone of the injured hemisphere on the 1st, 3rd, 7th, and 14th day after the onset of ischemia. Correlations between the number of nestin-positive (nestin

Indexed as

caspase-3cerebral ischemia/reperfusion injurymild hypothermianestinsub-granular zone

Identifiers

PMID29312600
PMCPMC5752513
OpenAlexW2771016967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.