ArticleOncotarget2017
Histopathological, molecular, clinical and radiological characterization of rosette-forming glioneuronal tumor in the central nervous system.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Subtotal resection and adjuvant radiotherapy for a fourth ventricle rosette-forming glioneuronal tumor in a child: a case report and review of management strategies.Annals of medicine and surgery (2012) · 2026Article
- Rosette-forming glioneuronal tumor of the cerebellum with intratumoral hemorrhage: case report with radiologic-pathologic correlation in a resource-limited setting.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Stereotactic radiosurgery for residual rosette-forming glioneuronal tumor: a case report and literature review.Acta neurochirurgica · 2026Review
- Novel insights toward diagnosis and treatment of glioneuronal and neuronal tumors in young adults.CNS oncology · 2024Review
- The Clinical and Molecular Landscape of Rosette-Forming Glioneuronal Tumors.Biomedicines · 2024Review
- Paediatric low-grade glioma: the role of classical pathology in integrated diagnostic practice.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Clinicopathological analysis of rosette-forming glioneuronal tumors.Diagnostic pathology · 2024Review
- Molecular characterization of gliomas and glioneuronal tumors amid Noonan syndrome: cancer predisposition examined.Frontiers in oncology · 2024Article
- Recurrent anaplastic transformation of a Vermian region rosette forming glioneuronal tumour - A rare entity. Case report and review of literature.International journal of surgery case reports · 2023Article
- Other Less Prevalent Tumors of the Central Nervous System.Advances in experimental medicine and biology · 2023Article
- Article
- Multisegmental versus monosegmental intramedullary spinal cord ependymomas: perioperative neurological functions and surgical outcomes.Neurosurgical review · 2022Article
- Rosette-forming glioneuronal tumours: two case reports and a review of the literature.BJR case reports · 2022Article
- Molecular analyses of rosette-forming glioneuronal tumor of the midbrain tegmentum: A report of two cases and a review of the FGFR1 status in unusual tumor locations.Surgical neurology international · 2022Article
- Spinal rosette-forming glioneuronal tumor: First case in a young child.Radiology case reports · 2021Article
- The rosette-forming glioneuronal tumor mimicked cerebral cysticercosis: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Rosette-Forming Glioneural tumor of the fourth ventricle: A case report and literature review.Neurosciences (Riyadh, Saudi Arabia) · 2021Review
- Rosette-forming glioneuronal tumor of the fourth ventricle; A case report and review of the literature.Clinical case reports · 2021Article
- Rosette-forming glioneuronal tumor: an update.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020Review
- Supratentorial intraventricular rosette-forming glioneuronal tumors - Case report and review of treatment paradigms.Surgical neurology international · 2020Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA rosette-forming glioneuronal tumor (RGNT) is a rare entity originally described in the fourth ventricle. Recently, RGNTs occurring in extraventricular sites and those with malignant behaviors have been reported. The purpose of this study was to analyze the clinicoradiological and histopathological features, therapeutic strategies, and outcomes of RGNTs.
methodsWe enrolled 38 patients diagnosed with RGNTs pathologically between August 2009 and June 2016. CT and MRI, including diffusion-weighted imaging and spectroscopy, were performed. The surgical treatment and histopathological and molecular features were assessed. Additionally, we searched the relevant literatures and performed a pooled analysis of individual patient data. The potential risk factors of prognosis were analyzed.
resultsOur case series included 22 male and 16 female patients, with a mean age of 25.9 years. RGNTs involved the fourth ventricle (26.3%), cerebella (34.2%), supratentorial ventricular system (13.2%), spinal cord (10.5%), temporal lobe (10.5%), thalamus (7.9%), brain stem (7.9%), frontal lobe (5.3%), pineal region (5.3%), suprasellar region (2.6%), and basal ganglia (2.6%). Statistical analyses showed that pediatric age, purely solid appearance of the tumor, and inadequate resection (only partial removal or biopsy) were risk factors associated with progression events. Patients with subtotal resection appeared to do as well as those with gross total resection.
conclusionsRGNTs can occur nearly anywhere in the CNS, at both supratentorial and infratentorial sites. Maximal safe surgical resection should be emphasized for treatment; whilst aggressive resection with the goal of complete resection may be unnecessary.
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