Evidence map›Paper›PMID 29312596›Full record

ArticleOncotarget2017

RA and ω-3 PUFA co-treatment activates autophagy in cancer cells.

Shenglong Zhu, Guangxiao Lin, Ci Song, Yikuan Wu, Ninghan Feng, Wei Chen, Zhao He, Yong Q Chen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Shenglong ZhuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Guangxiao LinState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Ci SongState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Yikuan WuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Ninghan FengWuxi Medical School, Jiangnan University, Wuxi, China.
Wei ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Zhao HeState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Yong Q ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
State Key Laboratory of Food Science and Technology · CNJiangnan University · CNWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinoic acid (RA), is a promising therapeutic agent for the treatment of breast cancer. However, metabolic disorders and drug resistance reduce the efficacy of RA. In this study, we found that RA and ω-3 polyunsaturated fatty acids (ω-3 PUFAs) synergistically induced cell death

Indexed as

autophagybreast cancerretinoic acidω-3 PUFAs

Identifiers

PMID29312596
PMCPMC5752509
OpenAlexW2768646191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.