Evidence map›Paper›PMID 29312533›Full record

ArticleOncotarget2017

Loss of PACS-2 delays regeneration in DSS-induced colitis but does not affect the

Sarah L Dombernowsky, Jeanette Schwarz, Jacob Samsøe-Petersen, Reidar Albrechtsen, Kim B Jensen, Gary Thomas, Marie Kveiborg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah L DombernowskyBiotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Jeanette SchwarzBiotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Jacob Samsøe-PetersenBiotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Reidar AlbrechtsenBiotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Kim B JensenBiotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Gary ThomasDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Marie KveiborgBiotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.

Funding

Allosteric regulation of SIRT1 by a PACS-2 and DBC1 regulatory hubR01DK114855 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRONENBORN, ANGELA M., THOMAS, GARY · 2017 to 2020
$2.4M
Regulation of TRAIL Induced Apoptosis in Cancer CellsR01CA151564 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMAS, GARY · 2011 to 2015
$1.6M
Regulation of PPAR alpha by PACS-2 in response to nutrient stressR01DK112844 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THOMAS, GARY · 2017 to 2019
$1.2M
NCI NIH HHS R01 CA151564NIDDK NIH HHS R01 DK112844NIDDK NIH HHS R01 DK114855
6 · The paper itself

Abstract

PACS-2 is a multifunctional sorting protein that mediates cell homeostasis. We recently identified PACS-2 in a functional genome-wide siRNA screen for novel regulators of the metalloproteinase ADAM17, the main sheddase for ligands of the ErbB receptor family. Of note, we showed that

Indexed as

ADAM17ApcMin modelcolon cancerDSS-induced colitisPACS-2

Identifiers

PMID29312533
PMCPMC5752446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.