ArticleAmerican journal of translational research2017
MiR-30a attenuates osteoclastogenesis via targeting DC-STAMP-c-Fos-NFATc1 signaling.
Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- DC-STAMP activates the PI3K/AKT/mTOR signaling pathway to regulate PANoptosis in acute myeloid leukemia.PloS one · 2026Article
- Association between dietary selenium intake and the prevalence of osteoporosis and its role in the treatment of glucocorticoid-induced osteoporosis.Journal of orthopaedic surgery and research · 2023Article
- Role and Regulation of Transcription Factors in Osteoclastogenesis.International journal of molecular sciences · 2023Review
- MiR-30 Family: A Novel Avenue for Treating Bone and Joint Diseases?International journal of medical sciences · 2023Review
- Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients.Frontiers in oncology · 2023Article
- Compression loading of osteoclasts attenuated microRNA-146a-5p expression, which promotes angiogenesis by targeting adiponectin.Science China. Life sciences · 2022Article
- Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression.Acta pharmacologica Sinica · 2021Article
- MicroRNA-196a-5p in Extracellular Vesicles Secreted from Myoblasts Suppresses Osteoclast-like Cell Formation in Mouse Cells.Calcified tissue international · 2021Article
- A Nitrobenzoyl Sesquiterpenoid Insulicolide A Prevents Osteoclast FormationFrontiers in pharmacology · 2021Article
- GATA4-driven miR-206-3p signatures control orofacial bone development by regulating osteogenic and osteoclastic activity.Theranostics · 2021Article
- Noncoding RNAs in subchondral bone osteoclast function and their therapeutic potential for osteoarthritis.Arthritis research & therapy · 2020Review
- Osteoclast Fusion: Physiological Regulation of Multinucleation through Heterogeneity-Potential Implications for Drug Sensitivity.International journal of molecular sciences · 2020Review
- Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis.International journal of molecular sciences · 2020Review
- Osteoclast Multinucleation: Review of Current Literature.International journal of molecular sciences · 2020Review
- Involvement of Noncoding RNAs in the Differentiation of Osteoclasts.Stem cells international · 2020Review
- Role of cancer stem cells in the development of giant cell tumor of bone.Cancer cell international · 2020Review
- MicroRNAs: Key Regulators to Understand Osteoclast Differentiation?Frontiers in immunology · 2019Review
- miR-193-3p ameliorates bone resorption in ovariectomized mice by blocking NFATc1 signaling.International journal of clinical and experimental pathology · 2019Article
- Down-regulation of miR-30a-5p is Associated with Poor Prognosis and Promotes Chemoresistance of Gemcitabine in Pancreatic Ductal Adenocarcinoma.Journal of Cancer · 2019Article
- GAG and collagen II attenuate glucocorticoid-induced osteoporosis by regulating NF-κB and MAPK signaling.American journal of translational research · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoclast is a kind of unique cells which is responsible for bone matrix absorption. It was widely reported that microRNAs (miRNAs) could regulate several physiological processes, including osteoclastogenesis. In our study, microarray analysis showed that miR-30a was down-regulated during osteoclastogenesis after RANKL (receptor activator of nuclear factor κB ligand) stimulation. Osteoclasts and actin-ring formation as well as bone resorption were inhibited when miR-30a was overexpressed in osteoclast precursor cells. Meantime, when miR-30a was inhibited in osteoclast precursor cells, osteoclasts and actin-ring formation as well as bone resorption were promoted. Furthermore, we discovered that miR-30a overexpression inhibited the protein levels of DC-STAMP, c-Fos and NFATc1. However, when DC-STAMP was inhibited by using a DC-STAMP siRNA, we could not detect the inhibition effect of osteoclastogenesis and bone resorption induced by miR-30a. In conclusion, miR-30a attenuated osteoclastogenesis via suppression of DC-STAMP-c-Fos-NFATc1 signaling pathway. On these grounds, this study may reveal a new promising target for the treatment of osteoporosis and other osteopenic disorders.
Indexed as
Identifiers
29312525PMC5752923What OpenQuestion holds
Registered trials
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