Evidence map›Paper›PMID 29312512›Full record

ArticleAmerican journal of translational research2017

Rabbit model of subchondral bone bruise and the treatment potential of calcitonin.

Jinsong Hong, Ting Wang, Zhibin Chen, Haobo Pan, Xiaohua Pan

Abstract read
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In one paragraph

Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jinsong HongDepartment of Orthopedic and Traumatology, Guangzhou Orthopedic HospitalGuangzhou, China.
Ting WangCenter for Human Tissue and Organ Degeneration and Shenzhen Key Laboratory of Marine Biomedical Materials, Shenzhen Institutes of Advanced Technology, China Academy of ScienceShenzhen, China.
Zhibin ChenDepartment of Orthopedics and Traumatology, Bao'an Hospital Affiliated to Southern Medical University and Shenzhen Eighth People's HospitalShenzhen 518100, China.
Haobo PanCenter for Human Tissue and Organ Degeneration and Shenzhen Key Laboratory of Marine Biomedical Materials, Shenzhen Institutes of Advanced Technology, China Academy of ScienceShenzhen, China.
Xiaohua PanDepartment of Orthopedics and Traumatology, Bao'an Hospital Affiliated to Southern Medical University and Shenzhen Eighth People's HospitalShenzhen 518100, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study characterized a novel rabbit model of subchondral bone bruise and investigated the intervening effect of calcitonin.

methodsBone bruise was implemented via controlled free-fall counterpoise on the medial tibial subchondral bone of 5-month-old New Zealand rabbits, with 3, 2.5, or 2 Joules of energy. Subsequent subchondral bone bruise was characterized via magnetic resonance imaging, micro computed tomography, and histology. Calcitonin was administered for 3 weeks, and the changes in subchondral bone were characterized.

resultsThe severity of subchondral bone bruise lesions correlated with the energy applied. The lesions involved trabecular separation and reduced trabecular number, with bone marrow edema and trabecular micro-fracture. With calcitonin treatment, subchondral bone marrow edema subsided and trabecular ultrastructure repaired.

conclusionFree fall counterpoise is a promising method to establish a subchondral bone bruise model in rabbits. Calcitonin injection is a potential treatment for subchondral bone bruise lesions.

Indexed as

calcitoninmagnetic resonance imagingRabbits modelsubchondral bone bruise

Identifiers

PMID29312512
PMCPMC5752910

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.