Evidence map›Paper›PMID 29312505›Full record

ArticleAmerican journal of translational research2017

Curcumin inhibits gastric cancer-derived mesenchymal stem cells mediated angiogenesis by regulating NF-κB/VEGF signaling.

Feng Huang, Yongliang Yao, Jianhong Wu, Qingqian Liu, Jiao Zhang, Xiongyong Pu, Qiang Zhang, Longfei Xia

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 45 citations in OpenAlex.

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  6. Cancer chemoprevention: signaling pathways and strategic approaches.Signal transduction and targeted therapy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Feng HuangDepartment of Clinical Laboratory, The First People's Hospital of Kunshan Affiliated with Jiangsu UniversitySuzhou 215300, China.
Yongliang YaoDepartment of Clinical Laboratory, The First People's Hospital of Kunshan Affiliated with Jiangsu UniversitySuzhou 215300, China.
Jianhong WuDepartment of Clinical Laboratory, The First People's Hospital of Kunshan Affiliated with Jiangsu UniversitySuzhou 215300, China.
Qingqian LiuDepartment of Clinical Laboratory, The First People's Hospital of Kunshan Affiliated with Jiangsu UniversitySuzhou 215300, China.
Jiao ZhangDepartment of Clinical Laboratory, The First People's Hospital of Kunshan Affiliated with Jiangsu UniversitySuzhou 215300, China.
Xiongyong PuDepartment of Clinical Laboratory, The First People's Hospital of Kunshan Affiliated with Jiangsu UniversitySuzhou 215300, China.
Qiang ZhangDepartment of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233004, China.
Longfei XiaSchool of Medicine, Jiangsu UniversityZhenjiang 212013, China.
Jiangsu University · CNFirst Affiliated Hospital of Bengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer-derived mesenchymal stem cells (MSCs) seem to play an important role in mediating tumor angiogenesis. Recently, curcumin has been shown to display multiple therapeutic properties, including anticancer activity. In the present study, we have tried to explore the role of curcumin in regulating gastric cancer cells-derived mesenchymal stem cells (GC-MSCs) mediated angiogenesis. Our results showed that curcumin attenuated the high expression levels of fibroblast proteins (α-SMA & Vimentin) in GC-MSCs. Its treatment also inhibited GC-MSCs induced human umbilical vein endothelial cells (HUVEC) tube formation, migration and colony formation. Furthermore, it was noticed that curcumin abrogated NF-κB signaling activity and VEGF production in GC-MSCs. Next, to establish the link between regulation of NF-κB/VEGF signaling by curcumin, and its influence on GC-MSC-derived angiogenesis, we pretreated GC-MSCs with either NF-κB inhibitor PDTC or a neutralizing antibody against VEGF (NA-VEGF), and then collected conditioned media (CM). The HUVEC cells were then cultured in this conditioned media to test their ability to form tubes, migrate and form colonies. Our results demonstrated that NF-κB/VEGF signaling is important for GC-MSCs induced tube formation, migration and colony formation in HUVEC cells. Moreover, we also observed that NF-κB/VEGF signaling regulated VEGF expression of gastric cancer cells both

Indexed as

CurcuminMSCNF-κBtumor angiogenesisVEGF

Identifiers

PMID29312505
PMCPMC5752903
OpenAlexW2977689981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.