Evidence map›Paper›PMID 29312494›Full record

ArticleAmerican journal of translational research2017

Depletion of astrocyte elevated gene-1 suppresses tumorigenesis through inhibition of Akt activity in bladder cancer cells.

Lianhua Zhang, Guoliang Yang, Haige Chen, Yiran Huang, Wei Xue, Juanjie Bo

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04286672 (Serum Metadherin mRNA Expression in Bladder Cancer), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04286672 unknown statusnot on this mapstarted 2020, after this paper: background citation

Serum Metadherin mRNA Expression in Bladder Cancer

TypeobservationalSponsorAssiut UniversityRan2020 to 2022Enrolled70ConditionsBladder CancerArmsMetadherin
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Expression and correlation ofTranslational cancer research · 2020
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lianhua ZhangDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai 200127, China.
Guoliang YangDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai 200127, China.
Haige ChenDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai 200127, China.
Yiran HuangDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai 200127, China.
Wei XueDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai 200127, China.
Juanjie BoDepartment of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai 200127, China.
Renji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocyte elevated gene-1 (AEG-1) has been reported to promote tumorigenesis, however the molecular mechanisms by which AEG-1-induced bladder cancer progression has remained elusive. Here, we identified that depletion of AEG-1 in bladder cancer cells suppressed cell growth. Moreover, we observed that down-regulation of AEG-1 induced apoptosis and inhibited cell migration and invasion. Furthermore, depletion of AEG-1 inhibited Akt activity and suppressed Bcl-2 expression, but upregulated the levels of p21 and p27. Our findings reveal that AEG-1 carries out its oncogenic function via activation of the Akt pathway. Therefore, inhibition of AEG-1 could be a novel treatment approach for bladder cancer.

Indexed as

AEG-1bladder cancerinvasionpAktproliferation

Identifiers

PMID29312494
PMCPMC5752892
OpenAlexW2924976093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.