Evidence map›Paper›PMID 29312483›Full record

ArticleAmerican journal of translational research2017

Preparation of laminin/nidogen adsorbed urinary bladder decellularized materials via a mussel-inspired polydopamine coating for pelvic reconstruction.

Liangpeng Ge, Chuan Cao, Shixuan Chen, Bin Shao, Qianyong Li, Qingtao Li, Lubin Liu, Zhiqing Liang, Yong Huang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Liangpeng GeChongqing Academy of Animal SciencesChongqing, China.
Chuan CaoDepartment of Plastic and Reconstructive Surgery, Southwestern Hospital, Third Military Medical UniversityChongqing 400038, China.
Shixuan ChenDepartment of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical CenterOmaha, Nebraska 68198, United States.
Bin ShaoDepartment of Veterinary, Rongchang Campus, Southwest UniversityChongqing, China.
Qianyong LiDepartment of Veterinary, Rongchang Campus, Southwest UniversityChongqing, China.
Qingtao LiSchool of Medicine, South China University of TechnologyChina.
Lubin LiuChongqing Health Center for Women and Children, Chongqing Obstetric and Gynecologic HospitalChongqing, China.
Zhiqing LiangDepartment of Plastic and Reconstructive Surgery, Southwestern Hospital, Third Military Medical UniversityChongqing 400038, China.
Yong HuangKey Laboratory of Pig Industry Sciences, Ministry of AgricultureChongqing, China.
Army Medical University · CNSouthwest University · CNChongqing Academy of Animal Science · CNChongqing Maternal and Child Health Hospital · CNNebraska Medical Center · USSouth China University of Technology · CNZigong Light Industry Design Institute (China) · CN

Funding

Adolescents with Major Depression and AUD: Community-Based Integrated TreatmentR01AA020705 · NIAAA · BROWN UNIVERSITY · PI SPIRITO, ANTHONY · 2012 to 2016
$3.3M
NIAAA NIH HHS R01 AA020705
6 · The paper itself

Abstract

Pelvic organ prolapse (POP) is a serious health issue that affects many adult women. A common strategy for POP reconstruction is to use scaffold materials to reconstruct the prolapsed pelvic organ. However, the existing materials for pelvic reconstruction do not meet the clinical requirements for biocompatibility, mechanics and immunological rejection. To address these concerns, urinary bladder decellularized materials (UBDM) was selected due to their good strain-stress resistance. To enhance its biocompatibility, laminin/nidogen was used to modify the UBDM with a mussel-inspired polydopamine coating. We found that the biocompatibility and mechanical properties of laminin/nidogen-Dopamine-UBDM were significantly enhanced and that the degradation rate of laminin/nidogen-Dopamine-UBDM was markedly reduced. Moreover, the expression of CD31 in the laminin/nidogen-Dopamine-UBDM group was higher than that in the normal UBDM group. The laminin/nidogen-Dopamine-UBDM treatment mainly guided M2 type macrophages and led to an inflammatory response. These results indicate that laminin/nidogen adsorbed urinary bladder decellularized materials are promising for use in pelvic reconstruction.

Indexed as

decellularizationdopaminelaminin/nidogenPelvic organ prolapsereconstructionurinary bladder

Identifiers

PMID29312483
PMCPMC5752881
OpenAlexW2987170989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.