ArticleJournal of foot and ankle research2018
Survival and associated risk factors in patients with diabetes and amputations caused by infectious foot gangrene.
Article in Journal of foot and ankle research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Clinical Classification of the Diabetic Foot Syndrome Adapted to ICD-10 as a Solution to the Problem of Diagnostics, Statistics and Standardisation.Medicina (Kaunas, Lithuania) · 2021Trial
- Sirt1 transgene delivery improves diabetes-impaired wound healing.Bioactive materials · 2026Article
- Marine-Derived Polyketides fromACS pharmacology & translational science · 2026Article
- Epidemiological trends in bacterial resistance in diabetic foot infections across the COVID-19 timeline: a retrospective analysis.IJID regions · 2026Article
- Correlation study on the risk of cardiovascular adverse events in diabetic foot patients based on machine learning - a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Repurposing Antidiabetic Drugs for Gangrene: A Mendelian Randomization and Text Mining Study.International journal of medical sciences · 2025Article
- Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing.International journal of molecular sciences · 2024Review
- Risk Factors for Major Lower Limb Amputation and Effect of Endovascular Revascularization in Patients with Diabetic Foot Wound.Indian journal of orthopaedics · 2024Article
- Preclinical study of diabetic foot ulcers: From pathogenesis to vivo/vitro models and clinical therapeutic transformation.International wound journal · 2023Review
- Hybrid Regenerative Therapy for Successful Reconstruction of an Infected Traumatized Diabetic Foot Wound.Plastic and reconstructive surgery. Global open · 2023Article
- Salami-Tactics: when is it time for a major cut after multiple minor amputations?Archives of orthopaedic and trauma surgery · 2023Article
- Diabetes Distal Peripheral Neuropathy: Subtypes and Diagnostic and Screening Technologies.Journal of diabetes science and technology · 2022Review
- Impact of wound microbiology on limb preservation in patients with diabetic foot infection.Journal of diabetes investigation · 2022Article
- Use of Copper Nanoparticles to Reduce Bioburden in the Treatment of Diabetic Foot Ulcers.Eplasty · 2022Article
- Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats.Antibiotics (Basel, Switzerland) · 2021Article
- Five-year mortality rate for patients with diabetic hand gangrene who undergo upper extremity amputation.Acta orthopaedica et traumatologica turcica · 2021Article
- Availability and service provision of multidisciplinary diabetes foot units in Australia: a cross-sectional survey.Journal of foot and ankle research · 2021Article
- Article
- Major Amputation Profoundly Increases Mortality in Patients With Diabetic Foot Infection.Frontiers in surgery · 2021Article
- Survival at 10 years following lower extremity amputations in patients with diabetic foot disease.Endocrine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfectious gangrene of the foot is a serious complication of diabetes that usually leads to a certain level of lower-extremity amputation (LEA). Nevertheless, the long-term survival and factors associated with mortality in such patients have yet to be elucidated.
methodsA total of 157 patients with type 2 diabetes who received treatment for infectious foot gangrene at a major diabetic foot center in Taiwan from 2002 to 2009 were enrolled, of whom 90 had major LEAs (above the ankle) and 67 had minor LEAs (below the ankle). Clinical data during treatment were used for the analysis of survival and LEA, and survival was tracked after treatment until December 2012.
resultsOf the 157 patients, 109 died, with a median survival time of 3.12 years and 5-year survival rate of 40%. Age [hazard ratio 1.04 (95% confidence interval 1.01-1.06)], and major LEA [1.80 (1.05-3.09)] were independent factors associated with mortality. Patients with minor LEAs had a better median survival than those with major LEAs (5.5 and 1.9 years, respectively,
conclusionsEfforts to limit amputations below the ankle resulted in better survival of patients with infectious foot gangrene. An abnormal ankle-brachial index may guide physicians to make appropriate decisions with regards to the amputation level.
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