Evidence map›Paper›PMID 29312341›Full record

ArticleFrontiers in immunology2017

Mucosal-Associated Invariant T Cells Display a Poor Reconstitution and Altered Phenotype after Allogeneic Hematopoietic Stem Cell Transplantation.

Martin Solders, Tom Erkers, Laia Gorchs, Thomas Poiret, Mats Remberger, Isabelle Magalhaes, Helen Kaipe

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

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  4. Mucosal-associated invariant T cells for cancer immunotherapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Martin SoldersDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Tom ErkersBlood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, United States.
Laia GorchsDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Thomas PoiretDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Mats RembergerCenter for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden.
Isabelle MagalhaesDepartment of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Helen KaipeDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SEStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells are innate-like T cells which are important in the defense against certain bacteria and yeast. The reconstitution of MAIT cells after allogeneic hematopoietic stem cell transplantation (HSCT) is not known. We investigated MAIT cell phenotype and function in 17 patients devoid of relapse and severe graft-versus-host disease (GvHD) in paired samples collected 1-2, 3-6, 12, and 24 months after transplantation. Data were compared to 17 healthy controls (HC), as well as 22 patients with acute GvHD grade 2-3. The frequency of MAIT cells within CD3

Indexed as

allogeneic hematopoietic stem cell transplantationcyclosporin Agraft-versus-host diseaseimmune reconstitutionmucosal-associated invariant T cellsPD-1sirolimus

Identifiers

PMID29312341
PMCPMC5742569
OpenAlexW2779408740

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.