Evidence map›Paper›PMID 29312318›Full record

ArticleFrontiers in immunology2017

Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/K

Kang Tang, Linfeng Cheng, Chunmei Zhang, Yusi Zhang, Xuyang Zheng, Yun Zhang, Ran Zhuang, Boquan Jin, Fanglin Zhang, Ying Ma

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  3. Review
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  8. Article
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  10. IL-15 induced bystander activation of CD8Frontiers in cellular and infection microbiology · 2022
    Article
  11. Protective CD8Virology journal · 2020
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kang TangDepartment of Immunology, The Fourth Military Medical University, Xi'an, China.
Linfeng ChengDepartment of Microbiology, The Fourth Military Medical University, Xi'an, China.
Chunmei ZhangDepartment of Immunology, The Fourth Military Medical University, Xi'an, China.
Yusi ZhangDepartment of Immunology, The Fourth Military Medical University, Xi'an, China.
Xuyang ZhengDepartment of Infectious Diseases, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Yun ZhangDepartment of Immunology, The Fourth Military Medical University, Xi'an, China.
Ran ZhuangDepartment of Immunology, The Fourth Military Medical University, Xi'an, China.
Boquan JinDepartment of Immunology, The Fourth Military Medical University, Xi'an, China.
Fanglin ZhangDepartment of Microbiology, The Fourth Military Medical University, Xi'an, China.
Ying MaDepartment of Immunology, The Fourth Military Medical University, Xi'an, China.
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hantaan virus (HTNV) infections can cause severe hemorrhagic fever with renal syndrome (HFRS) in humans, which is associated with high fatality rates. Cytotoxic T cell (CTL) responses contribute to virus elimination; however, to date, HLA class I allele-restricted HTNV glycoprotein (GP) epitopes recognized by CTLs have not been reported, limiting our understanding of CTL responses against HTNV infection in humans. In this study, 34 HTNV GP nine-mer epitopes that may bind to HLA-A*0201 molecules were predicted using the BIMAS and SYFPEITHI database. Seven of the epitopes were demonstrated to bind to HLA-A*0201 molecules with high affinity

Indexed as

cytotoxic T-cell epitopecytotoxic T-cell responseHantaan virushemorrhagic fever with renal syndromeHLA-A*0201HLA-A2.1/Kb transgenic micepeptide vaccine

Identifiers

PMID29312318
PMCPMC5732971
OpenAlexW2773804654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.