Evidence map›Paper›PMID 29312314›Full record

ArticleFrontiers in immunology2017

Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5

Yan-Mei Jiao, Hong-Ge Yang, Hui-Huang Huang, Bo Tu, Shao-Jun Xing, Lin Mao, Wei Xia, Ran He, Ji-Yuan Zhang, Ruo-Nan Xu and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. C-X-C chemokine receptor type 5World journal of gastroenterology · 2025
    Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. An angel or a devil? Current view on the role of CD8Journal of translational medicine · 2024
    Review
  8. Review
  9. Cytolytic CD8Science immunology · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. The diagnostic role of PD-1Journal of clinical laboratory analysis · 2022
    Article
  14. Review
  15. Article
  16. CXCR5Journal of immunology (Baltimore, Md. : 1950) · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. CXCR5+ CD8 T Cells: Protective or Pathogenic?Frontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

Yan-Mei JiaoTreatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China.
Hong-Ge YangSavaid Medical School, University of Chinese Academy of Sciences, Beijing, China.
Hui-Huang HuangTreatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China.
Bo TuTreatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China.
Shao-Jun XingDepartment of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.
Lin MaoYunnan Provincial Hospital of Infectious Diseases, Kunming, China.
Wei XiaCenter for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Ran HeInstitute of Immunology, Third Military Medical University, Chongqing, China.
Ji-Yuan ZhangTreatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China.
Ruo-Nan XuTreatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China.
Lei JinTreatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China.
Ming ShiTreatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China.
Zhe XuTreatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China.
En-Qiang QinTreatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China.
Xi-Cheng WangYunnan Provincial Hospital of Infectious Diseases, Kunming, China.
Hao WuCenter for Infectious Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
Lilin YeInstitute of Immunology, Third Military Medical University, Chongqing, China.
Fu-Sheng WangTreatment and Research Center for Infectious Diseases, Beijing 302 Hospital, Beijing, China.
302 Military Hospital of China · CNArmy Medical University · CNYunnan Provincial Infectious Disease Hospital · CNBeijing YouAn Hospital · CNCapital Medical University · CNUniversity of Chinese Academy of Sciences · CNUniversity of Iowa · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCXCR5

methodsWe enrolled a total of 101 HIV patients, including 62 typical progressors, 26 complete responders (CRs), and 13 immune non-responders (INRs). Flow cytometric analysis, immunohistochemical staining, and relative function (i.e., cytokine secretion and PD-1 blockade) assays were performed to analyze the properties of CXCR5

resultsHIV-specific CXCR5

conclusionPD-1

Indexed as

CXCR5+CD8+ T cellsCXCR5−CD8− T cellscytotoxic T cellsHIVprogrammed cell death 1

Identifiers

PMID29312314
PMCPMC5732951
OpenAlexW2774699266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.