Evidence map›Paper›PMID 29312287›Full record

ArticleFrontiers in immunology2017

Invariant Natural Killer T Cells Ameliorate Monosodium Urate Crystal-Induced Gouty Inflammation in Mice.

Jie Wang, Qibin Yang, Quanbo Zhang, Congcong Yin, Li Zhou, Jingguo Zhou, Yangang Wang, Qing-Sheng Mi

Abstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  6. Review
  7. Article
  8. Network Pharmacology Study onInternational journal of molecular sciences · 2021
    Article
  9. Autoinflammatory Features in Gouty Arthritis.Journal of clinical medicine · 2021
    Review
  10. Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jie WangDepartment of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, China.
Qibin YangImmunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, United States.
Quanbo ZhangImmunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, United States.
Congcong YinImmunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, United States.
Li ZhouImmunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, United States.
Jingguo ZhouDepartment of Rheumatology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Yangang WangDepartment of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, China.
Qing-Sheng MiImmunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, United States.

Funding

microRNAs and NKT cell development and functionR01AI119041 · NIAID · HENRY FORD HEALTH SYSTEM · PI MI, QING-SHENG · 2016 to 2020
$1.8M
NIAID NIH HHS R01 AI119041
6 · The paper itself

Abstract

Gout is an inflammatory arthritis caused by deposition of intra-articular monosodium urate (MSU) crystal. Previous studies have focused on resident macrophage, infiltrating monocyte, and neutrophil responses to MSU crystal; yet the mechanisms of cellular changes and the potential involvement of other regulatory immune cells remain largely unknown. Invariant natural killer T (

Indexed as

goutinvariant natural killer T cellsmacrophagepolarizationtumor necrosis factor-α

Identifiers

PMID29312287
PMCPMC5733058

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.