Evidence map›Paper›PMID 29311920›Full record

ArticleFrontiers in pharmacology2017

Modulation of miR-26a-5p and miR-15b-5p Exosomal Expression Associated with Clopidogrel-Induced Hepatotoxicity in HepG2 Cells.

Renata C Costa de Freitas, Raul H Bortolin, Mariana B Lopes, Letícia Tamborlin, Letícia Meneguello, Vivian N Silbiger, Rosario D C Hirata, Mário H Hirata, Augusto D Luchessi, André D Luchessi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Renata C Costa de FreitasDepartment of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, Brazil.
Raul H BortolinDepartment of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, Brazil.
Mariana B LopesDepartment of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, Brazil.
Letícia TamborlinLaboratory of Biotechnology, School of Applied Sciences, University of Campinas, Limeira, Brazil.
Letícia MeneguelloPost graduation in Biological Science, Institute of Biosciences, São Paulo State University (UNESP), Rio Claro, Brazil.
Vivian N SilbigerDepartment of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, Brazil.
Rosario D C HirataDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Mário H HirataDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Augusto D LuchessiLaboratory of Biotechnology, School of Applied Sciences, University of Campinas, Limeira, Brazil.
André D LuchessiDepartment of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal do Rio Grande do Norte · BRUniversidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived miRNAs may be useful for improved monitoring of drug response and hepatotoxicity risk. In the present study, the expression of several exosomal miRNAs (miR-26a-5p, miR-145-5p, miR-15b-5p, and miR-4701-3p) and cell-derived mRNA targets (

Indexed as

clopidogrelhepatotoxicityHepG2 cell linemicroRNAs

Identifiers

PMID29311920
PMCPMC5733064
OpenAlexW2774377675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.