ArticleFrontiers in neural circuits2017
Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons.
Article in Frontiers in neural circuits, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Effect of muscarinic blockade on the speed of attention shifting, read-out delays and learning.Psychopharmacology · 2025Trial
- Receptor architecture of the macaque lateral geniculate nucleus.Brain structure & function · 2026Article
- Regional cerebral cholinergic vesicular transporter correlates of visual contrast sensitivity in Parkinson's disease: Implications for visual and cognitive function.Parkinsonism & related disorders · 2025Article
- Activation of M1 cholinergic receptors in mouse somatosensory cortex enhances information processing and detection behaviour.Communications biology · 2024Article
- Neocortical layer 5 subclasses: From cellular properties to roles in behavior.Frontiers in synaptic neuroscience · 2022Review
- Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface.Nature communications · 2021Article
- Contribution of Ionotropic Glutamatergic Receptors to Excitability and Attentional Signals in Macaque Frontal Eye Field.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1.Scientific reports · 2021Article
- Muscarinic Acetylcholine Receptor Localization on Distinct Excitatory and Inhibitory Neurons Within the ACC and LPFC of the Rhesus Monkey.Frontiers in neural circuits · 2021Article
- Integrative analysis of in vivo recording with single-cell RNA-seq data reveals molecular properties of light-sensitive neurons in mouse V1.Protein & cell · 2020Article
- Transient neocortical gamma oscillations induced by neuronal response modulation.Journal of computational neuroscience · 2020Article
- Mechanisms underlying gain modulation in the cortex.Nature reviews. Neuroscience · 2020Review
- The Importance of Sensory Processing in Mental Health: A Proposed Addition to the Research Domain Criteria (RDoC) and Suggestions for RDoC 2.0.Frontiers in psychology · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Acetylcholine is a neuromodulator that shapes information processing in different cortical and subcortical areas. Cell type and location specific cholinergic receptor distributions suggest that acetylcholine in macaque striate cortex should boost feed-forward driven activity, while also reducing population excitability by increasing inhibitory tone. Studies using cholinergic agonists in anesthetized primate V1 have yielded conflicting evidence for such a proposal. Here we investigated how muscarinic or nicotinic receptor blockade affect neuronal excitability and contrast response functions in awake macaque area V1. Muscarinic or nicotinic receptor blockade caused reduced activity for all contrasts tested, without affecting the contrast where neurons reach their half maximal response (c50). The activity reduction upon muscarinic and nicotinic blockade resulted in reduced neuronal contrast sensitivity, as assessed through neurometric functions. In the majority of cells receptor blockade was best described by a response gain model (a multiplicative scaling of responses), indicating that ACh is involved in signal enhancement, not saliency filtering in macaque V1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.