Evidence map›Paper›PMID 29311837›Full record

ArticleFrontiers in cellular neuroscience2017

Generation of Otic Sensory Neurons from Mouse Embryonic Stem Cells in 3D Culture.

Michael Perny, Ching-Chia Ting, Sonja Kleinlogel, Pascal Senn, Marta Roccio

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Inner Ear Organoids: Recent Progress and Challenges.Stem cell reviews and reports · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
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  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Cochlear Sox2Frontiers in cell and developmental biology · 2021
    Article
  15. Stem Cell-Based Therapies in Hearing Loss.Frontiers in cell and developmental biology · 2021
    Review
  16. Review
  17. Molecular Aspects of the Development and Function of Auditory Neurons.International journal of molecular sciences · 2020
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Michael PernyNeuroinfection Laboratory, Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
Ching-Chia TingLaboratory of Inner Ear Research, Department for BioMedical Research, University of Bern, Bern, Switzerland.
Sonja KleinlogelInstitute for Physiology, University of Bern, Bern, Switzerland.
Pascal SennLaboratory of Inner Ear Research, Department for BioMedical Research, University of Bern, Bern, Switzerland.
Marta RoccioLaboratory of Inner Ear Research, Department for BioMedical Research, University of Bern, Bern, Switzerland.
University Hospital of Bern · CHUniversity of Bern · CHUniversity Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The peripheral hearing process taking place in the cochlea mainly depends on two distinct sensory cell types: the mechanosensitive hair cells and the spiral ganglion neurons (SGNs). The first respond to the mechanical stimulation exerted by sound pressure waves on their hair bundles by releasing neurotransmitters and thereby activating the latter. Loss of these sensorineural cells is associated with permanent hearing loss. Stem cell-based approaches aiming at cell replacement or

Indexed as

3D culturein vitro mESC differentiationorganoidsotic developmentspiral ganglion neurons

Identifiers

PMID29311837
PMCPMC5742223
OpenAlexW2776509638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.