Evidence map›Paper›PMID 29311830›Full record

ArticleFrontiers in cellular neuroscience2017

Modulation of Murine Olivary Connexin 36 Gap Junctions by PKA and CaMKII.

Paolo Bazzigaluppi, Sheena C Isenia, Elize D Haasdijk, Ype Elgersma, Chris I De Zeeuw, Ruben S van der Giessen, Marcel T G de Jeu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The Roles of Calmodulin and CaMKII in Cx36 Plasticity.International journal of molecular sciences · 2021
    Review
  5. Endocytosis of Connexin 36 is Mediated by Interaction with Caveolin-1.International journal of molecular sciences · 2020
    Article
  6. Article
  7. Article
  8. Article
  9. Localization of Retinal CaFrontiers in molecular neuroscience · 2019
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Paolo BazzigaluppiDepartment of Neuroscience, Erasmus Medical Center, Rotterdam, Netherlands.
Sheena C IseniaDepartment of Neuroscience, Erasmus Medical Center, Rotterdam, Netherlands.
Elize D HaasdijkDepartment of Neuroscience, Erasmus Medical Center, Rotterdam, Netherlands.
Ype ElgersmaDepartment of Neuroscience, Erasmus Medical Center, Rotterdam, Netherlands.
Chris I De ZeeuwDepartment of Neuroscience, Erasmus Medical Center, Rotterdam, Netherlands.
Ruben S van der GiessenDepartment of Neuroscience, Erasmus Medical Center, Rotterdam, Netherlands.
Marcel T G de JeuDepartment of Neuroscience, Erasmus Medical Center, Rotterdam, Netherlands.
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inferior olive (IO) is a nucleus located in the brainstem and it is part of the olivo-cerebellar loop. This circuit plays a fundamental role in generation and acquisition of coherent motor patterns and it relies on synchronous activation of groups of Purkinje cells (PC) in the cerebellar cortex. IO neurons integrate their intrinsic oscillatory activity with excitatory inputs coming from the somatosensory system and inhibitory feedback coming from the cerebellar nuclei. Alongside these chemical synaptic inputs, IO neurons are coupled to one another via connexin 36 (Cx36) containing gap junctions (GJs) that create a functional syncytium between neurons. Communication between olivary neurons is regulated by these GJs and their correct functioning contributes to coherent oscillations in the IO and proper motor learning. Here, we explore the cellular pathways that can regulate the coupling between olivary neurons. We combined

Indexed as

electrical synapseinferior olivePKAtracer-couplingαCaMKIIβ-CaMKII

Identifiers

PMID29311830
PMCPMC5735106
OpenAlexW2771293930

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.