ArticleFrontiers in neuroscience2017
The Endosomal-Lysosomal Pathway Is Dysregulated by
Abstract read
In one paragraph
Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer's disease.Molecular neurodegeneration · 2022Pooled it
- APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer's disease: a systematic review.Alzheimer's research & therapy · 2020Pooled it
- Retromer-targeted therapy for neurodegenerative diseases.Molecular neurodegeneration · 2026Review
- Review
- SORL1 variant links endosomal amyloid precursor protein mis-sorting to axonal transport defects and neuronal dysfunction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- APOE4 disrupts the central dogma by arresting neuronal proteome dynamics.bioRxiv : the preprint server for biology · 2026Article
- Article
- Risk genes in progressive supranuclear palsy (PSP) affect integrity and function of microtubules.Frontiers in aging · 2026Review
- Periodontitis and Alzheimer's disease, common pathways in down syndrome.Frontiers in dental medicine · 2026Review
- Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction.Autophagy · 2025Article
- Investigating the Effects ofbioRxiv : the preprint server for biology · 2025Article
- APOE4-Aβ synergy drives brain network dysfunction and neuronal lysosomal-ER proteostasis dysregulation a preclinical Alzheimer's disease model.bioRxiv : the preprint server for biology · 2025Article
- Failure of lysosomal acidification and endomembrane network in neurodegeneration.Experimental & molecular medicine · 2025Review
- Aging, Rather than Genotype, Is the Principal Contributor to Differential Gene Expression Within Targeted Replacement APOE2, APOE3, and APOE4 Mouse Brain.Brain sciences · 2025Article
- ApoE4 disrupts intracellular trafficking and iron homeostasis in a reproducible iPSC-based model of human brain endothelial cells.Stem cell reports · 2025Article
- Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β-hexosaminidase is necessary for neuronal health.Nature communications · 2025Article
- Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein.Molecular neurodegeneration · 2025Review
- Review
- Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Alzheimer's Disease-Related Endosomal and Synaptic Dysfunction with Cholinergic Neurodegeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Lysosomal acidification impairment in astrocyte-mediated neuroinflammation.Journal of neuroinflammation · 2025Review
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Tal NurielDepartment of Pathology and Cell Biology, Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, Colombia University, New York, NY, United States.
Katherine Y PengDepartment of Neuroscience and Physiology, New York University Langone Medical Center, New York University, New York, NY, United States.
Archana AshokDepartment of Pathology and Cell Biology, Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, Colombia University, New York, NY, United States.
Allissa A DillmanCell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States.
Helen Y FigueroaDepartment of Pathology and Cell Biology, Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, Colombia University, New York, NY, United States.
Justin ApuzzoCenter for Dementia Research, Nathan S. Kline Institute, Orangeburg, NY, United States.
Jayanth AmbatDepartment of Pathology and Cell Biology, Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, Colombia University, New York, NY, United States.
Efrat LevyCenter for Dementia Research, Nathan S. Kline Institute, Orangeburg, NY, United States.
Mark R CooksonCell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States.
Paul M MathewsCenter for Dementia Research, Nathan S. Kline Institute, Orangeburg, NY, United States.
Karen E DuffDepartment of Pathology and Cell Biology, Taub Institute for Research of Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, Colombia University, New York, NY, United States.
Funding
Uncovering Alzheimer's disease risk mechanisms through neuron-specific analysis of autophagy and endosomal-lysosomal functionP01AG017617 · NIA · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI NIXON, RALPH A. · 2000 to 2021
$40.0MGene expression in the human brainZIAAG000947 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2009 to 2025
$7.2MTraining in Pharmacological SciencesT32GM066704 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BACH, ERIKA A · 2004 to 2018
$2.6MPostdoctoral Research Training in Neurodegenerative Disorders and the Aging BrainT32AG052909 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Helen E Scharfman, THOMAS M WISNIEWSKI · 2017 to 2026
$2.5MNeuronal Protective Apolipoprotein E2-mediated endocytic and exocytic pathwaysRF1AG057517 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEVY, EFRAT, MATHEWS, PAUL M · 2017 to 2020
$2.4MMetabolite profiling to identify AD-relevant pathways affected by apoe variantsR21AG048408 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DUFF, KAREN · 2014 to 2015
$458kProfiling Pathologically Normal ApoE Variants to Identify Pathways for ADR21NS071836 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DUFF, KAREN · 2010 to 2011
$455kMetabolomic/lipidomic analysis of apoE isoform effects in AD-linked brain regionsF32AG047797 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NURIEL, TAL · 2014 to 2016
$170kNIA NIH HHS F32 AG047797NIA NIH HHS P01 AG017617NIA NIH HHS R21 AG048408NIA NIH HHS RF1 AG057517NIA NIH HHS T32 AG052909NIGMS NIH HHS T32 GM066704NINDS NIH HHS R21 NS071836
Abstract
Possession of the ε4 allele of apolipoprotein E (
Indexed as
Alzheimer's diseaseAPOEAPOE4Apolipoprotein EendosomelysosomeRNA-seqtranscriptomics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.