Evidence map›Paper›PMID 29311765›Full record

ReviewFrontiers in neuroscience2017

And Then There Was Light: Perspectives of Optogenetics for Deep Brain Stimulation and Neuromodulation.

Jean Delbeke, Luis Hoffman, Katrien Mols, Dries Braeken, Dimiter Prodanov

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 87 citations in OpenAlex.

  1. Light-controlled disruption of cancer cell dormancy via photoswitchable stress hormone receptor degraders.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. A RAPID PROTOTYPING ENVIRONMENT FOR CLOSED-LOOP NEUROMODULATION USING THE BRAIN INTERCHANGE SYSTEM.Proceedings of the ... Design of Medical Devices Conference. Design of Medical Devices Conference · 2026
    Article
  6. Review
  7. Article
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  10. A Synchronous iEEG Data Acquisition Framework for Dual Brain Interchange Systems.The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. High frequency DBS-like optogenetic stimulation of nucleus accumbens dopamine D2 receptor-containing neurons attenuates cocaine reinstatement in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jean DelbekeLCEN3, Department of Neurology, Institute of Neuroscience, Ghent University, Ghent, Belgium.
Luis HoffmanNeuroscience Research Flanders, Leuven, Belgium.
Katrien MolsNeuroscience Research Flanders, Leuven, Belgium.
Dries BraekenLife Science and Imaging, Imec, Leuven, Belgium.
Dimiter ProdanovNeuroscience Research Flanders, Leuven, Belgium.
IMEC · BENeuroelectronics Research Flanders · BEGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep Brain Stimulation (DBS) has evolved into a well-accepted add-on treatment for patients with severe Parkinsons disease as well as for other chronic neurological conditions. The focal action of electrical stimulation can yield better responses and it exposes the patient to fewer side effects compared to pharmaceuticals distributed throughout the body toward the brain. On the other hand, the current practice of DBS is hampered by the relatively coarse level of neuromodulation achieved. Optogenetics, in contrast, offers the perspective of much more selective actions on the various physiological structures, provided that the stimulated cells are rendered sensitive to the action of light. Optogenetics has experienced tremendous progress since its first

Indexed as

biosafetydeep brain stimulationepilepsyneural prosthesisneuromodulationoptogoeneticsParkinson's diseaseviral vectors

Identifiers

PMID29311765
PMCPMC5732983
OpenAlexW2775469113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.