ArticleNature neuroscience2018
Simple integration of fast excitation and offset, delayed inhibition computes directional selectivity in Drosophila.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Distribution and voltage dependence of ion channels shape single-neuron computations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Population morphology implies a common developmental blueprint for Drosophila motion detectors.PLoS computational biology · 2026Article
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- Afterimages drive a shared visual motion-reversal illusion inbioRxiv : the preprint server for biology · 2026Article
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- Understanding the mechanism of facilitation in hoverfly TSDNs.PLoS computational biology · 2025Article
- Broken time-reversal symmetry in visual motion detection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Adaptation to visual sparsity enhances responses to isolated stimuli.Current biology : CB · 2024Article
- Article
- Optimization in Visual Motion Estimation.Annual review of vision science · 2024Review
- Broken time reversal symmetry in visual motion detection.bioRxiv : the preprint server for biology · 2024Article
- Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome.Neuron · 2024Article
- Connectomic reconstruction predicts the functional organization of visual inputs to the navigation center of thebioRxiv : the preprint server for biology · 2023Article
- Direct comparison reveals algorithmic similarities in fly and mouse visual motion detection.iScience · 2023Article
- A comprehensive neuroanatomical survey of thebioRxiv : the preprint server for biology · 2023Article
- Mapping of multiple neurotransmitter receptor subtypes and distinct protein complexes to the connectome.bioRxiv : the preprint server for biology · 2023Article
- Article
- Voltage to Calcium Transformation Enhances Direction Selectivity inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Excitatory and inhibitory neural dynamics jointly tune motion detection.Current biology : CB · 2022Article
- Article
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Authors and funding
3 authors.
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Abstract
A neuron that extracts directionally selective motion information from upstream signals lacking this selectivity must compare visual responses from spatially offset inputs. Distinguishing among prevailing algorithmic models for this computation requires measuring fast neuronal activity and inhibition. In the Drosophila melanogaster visual system, a fourth-order neuron-T4-is the first cell type in the ON pathway to exhibit directionally selective signals. Here we use in vivo whole-cell recordings of T4 to show that directional selectivity originates from simple integration of spatially offset fast excitatory and slow inhibitory inputs, resulting in a suppression of responses to the nonpreferred motion direction. We constructed a passive, conductance-based model of a T4 cell that accurately predicts the neuron's response to moving stimuli. These results connect the known circuit anatomy of the motion pathway to the algorithmic mechanism by which the direction of motion is computed.
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