Evidence map›Paper›PMID 29311718›Full record

ArticleScientific reports2018

Systematic analysis of the regulatory roles of microRNAs in postnatal maturation and metergasis of liver of breeder cocks.

Shengru Wu, Wei Guo, Saisai Liang, Hong Lu, Wenqiang Sun, Xiaochun Ren, Qingzhu Sun, Xiaojun Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shengru WuCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Wei GuoCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Saisai LiangCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Hong LuCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Wenqiang SunCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Xiaochun RenCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Qingzhu SunCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China.
Xiaojun YangCollege of Animal Science and Technology, Northwest A&F University, Yangling, 712100, Shaanxi, China. yangxj@nwsuaf.edu.cn.
Northwest A&F University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The liver function of chickens is intensively remodeled from birth to adult, which was validated by metabolomics research in the present study. In order to understand the roles of microRNAs (miRNA) in liver maturation and metergasis, miRNA expression profiles in livers of 20 male chicks aged one day and five adult cocks aged 35 weeks were determined. A total of 191 differentially expressed miRNAs with the criteria of P < 0.05 and fold changes either >1.5 or <0.67 and 32 differentially expressed miRNAs with the criteria of false discovery value (FDR) < 0.05 and fold changes either >1.5 or <0.67 were detected. Subsequently, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of the targets revealed that candidate miRNAs may involve in the regulation of hepatic metabolism and immune functions, and some pathways including cell cycle which were implicated in postnatal liver development. Furthermore, 1211 differentially expressed mRNAs (messenger RNA) in livers between the postnatal and matured chickens were used to define the roles of differentially expressed miRNAs in regulating the expression of target genes. Our results revealed the first miRNA profile related to the adaption of mature liver functions after birth in breeder cock.

Indexed as

Gene Expression RegulationMetabolomeRNA Interference3' Untranslated RegionsAnimalsEnergy MetabolismGas Chromatography-Mass SpectrometryGene Expression ProfilingGene Regulatory NetworksLiverMaleMetabolomicsMicroRNAsMolecular Sequence AnnotationReproducibility of ResultsTranscriptome3' Untranslated RegionsMicroRNAsTransforming Growth Factor beta

Identifiers

PMID29311718
PMCPMC5758705
OpenAlexW2782226562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.