SynthesisMolecular psychiatry2018
Meta-analysis of epigenome-wide association studies of cognitive abilities.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 4 pooled it
4.5field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.Molecular psychiatry · 2022Pooled it
- Pooled it
- Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults.Biological psychiatry · 2019Pooled it
- DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies.JAMA psychiatry · 2018Pooled it
- Development and validation of MethylCog, a blood DNA methylation proxy for cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Blood mitochondrial heteroplasmic variants and cognitive performance in late midlife: REGARDS study.BMC neurology · 2026Article
- Association Between Maternal Gestational Diabetes, Cord Blood DNA Methylation, and Offspring Neurodevelopment.International journal of molecular sciences · 2026Article
- Association of neighborhood and individual-level socioeconomic disadvantage in childhood and adulthood with cognitive function in mid-adulthood: Cardiovascular Risk in Young Finns Study.American journal of epidemiology · 2026Article
- DNA hypomethylation at specific CG-sites within TRAK1 is linked to the neurocognitive profile in Klinefelter syndrome.Molecular psychiatry · 2026Article
- Integration of multiomic and multi-phenotypic data identifies biological pathways associated with physical fitness.Communications biology · 2026Article
- Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization.npj aging · 2025Article
- Epigenetic clocks and DNA methylation biomarkers of brain health and disease.Nature reviews. Neurology · 2025Review
- Epigenome-wide association study of cerebrospinal fluid-based biomarkers of Alzheimer's disease in cognitively normal individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis.Journal of translational medicine · 2025Article
- Neighborhood environment associations with cognitive function and structural brain measures in older African Americans.BMC medicine · 2025Article
- BDNF methylation associated with stress in women: Novel insights in epigenetics and inflammation.Brain, behavior, & immunity - health · 2024Article
- Epigenetic Aging Associations With Psychoneurological Symptoms and Social Functioning in Adults With Sickle Cell Disease.Biological research for nursing · 2024Article
- Evaluating the association between placenta DNA methylation and cognitive functions in the offspring.Translational psychiatry · 2024Article
- DNA Methylation at C-Reactive Protein-Associated CpG Sites May Mediate the Pathway Between Educational Attainment and Cognition.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Article
Corrections and comments
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Authors and funding
47 authors at 20 institutions in 7 countries.
Riccardo E MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk.
Allan F McRaeInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0001-5286-5485
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Elena ColicinoColumbia University Mailman School of Public Health, New York, NY, USA.
Eilis HannonUniversity of Exeter Medical School, Exeter, UK.ORCID http://orcid.org/0000-0001-6840-072X
Shuo LiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2331-2448
Diddier PradaInstituto Nacional de Cancerologia, Mexico City, Mexico.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
Letizia TrevisiHarvard Medical School, Boston, MA, USA.
Pei-Chien TsaiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Dina VojinovicDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jeannette SiminoDepartment of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA.
Daniel LevyFramingham Heart Study, Framingham, MA, USA.
Chunyu LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Michael MendelsonFramingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0001-7590-3958
Claudia L SatizabalFramingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0002-1115-4430
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Min A JhunDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy.
Luigi FerrucciClinical Research Branch, National Institute on Aging, Baltimore, MD, USA.
Dena G HernandezLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Andrew B SingletonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Douglas P KielHarvard Medical School, Boston, MA, USA.
Robert R McLeanHarvard Medical School, Boston, MA, USA.
Allan C JustIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Joel SchwartzHarvard T.H. Chan School of Public Health, Boston, MA, USA.
Avron SpiroBoston University Schools of Public Health and Medicine, Boston, MA, USA.
Pantel VokonasBoston University Schools of Public Health and Medicine, Boston, MA, USA.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Andre G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Joyce B J van MeursDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Claire StevesDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Andrea A BaccarelliColumbia University Mailman School of Public Health, New York, NY, USA.
Jordana T BellDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Myriam FornageHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Yi-Hsiang HsuHarvard Medical School, Boston, MA, USA.
Jonathan MillIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Thomas H MosleyMIND Center, University of Mississippi Medical Center, Jackson, MS, USA.
Sudha SeshadriDepartment of Neurology, Boston University School of Medicine, Boston, MA, USA.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Boston University · USErasmus MC · NLHarvard University · USUniversity of Michigan · USKing's College London · GBNational Institutes of Health · USColumbia University · USIcahn School of Medicine at Mount Sinai · USJackson Memorial Hospital · USThe University of Queensland · AUUniversity of Edinburgh · GBAlzheimer Scotland · GBAzienda Sanitaria di Firenze · ITBoston Children's Hospital · USBroad Institute · USBrown Foundation · USChang Gung University · TWInstituto Nacional de Cancerología · MXNational Institute on Aging · USThe University of Texas Health Science Center at Houston · US
Funding
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7MFramingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MThe Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3MGenome wide SNP analysis in Parkinson's diseaseZIAAG000949 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW · 2009 to 2024
$12.6MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9MCharacterization of Normal Genomic VariabilityZIAAG000932 · NIA · NATIONAL INSTITUTE ON AGING · PI SINGLETON, ANDREW · 2009 to 2024
$11.3MARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5MARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4MARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5MBiotechnology and Biological Sciences Research Council BB/F019394/1Chief Scientist Office CZB/4/505Intramural NIH HHS Z01 AG000932Intramural NIH HHS Z01 AG000949Intramural NIH HHS Z99 AG999999Medical Research Council G0701120Medical Research Council G1001245Medical Research Council MR/K026992/1Medical Research Council MR/M013111/1NHLBI NIH HHS K99 HL136875NHLBI NIH HHS R01 HL133221NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIAMS NIH HHS R21 AR056405NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG054076NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R00 ES023450NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS087541
Abstract
Cognitive functions are important correlates of health outcomes across the life-course. Individual differences in cognitive functions are partly heritable. Epigenetic modifications, such as DNA methylation, are susceptible to both genetic and environmental factors and may provide insights into individual differences in cognitive functions. Epigenome-wide meta-analyses for blood-based DNA methylation levels at ~420,000 CpG sites were performed for seven measures of cognitive functioning using data from 11 cohorts. CpGs that passed a Bonferroni correction, adjusting for the number of CpGs and cognitive tests, were assessed for: longitudinal change; being under genetic control (methylation QTLs); and associations with brain health (structural MRI), brain methylation and Alzheimer's disease pathology. Across the seven measures of cognitive functioning (meta-analysis n range: 2557-6809), there were epigenome-wide significant (P < 1.7 × 10
Indexed as
AdultAgedAged, 80 and overCognitionCohort StudiesCpG IslandsDNA MethylationEpigenesis, GeneticFemaleGenome-Wide Association StudyGenomicsHumansMaleMiddle Aged
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