ArticleNature genetics2018
Loss-of-function mutations in ADCY3 cause monogenic severe obesity.
Open access · greenAbstract readLetter
In one paragraph
Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
What it found
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Who cites it
108 citing papers in PubMed, 189 citations in OpenAlex.
- Shared and distinct genetic architectures of eating disorders and obesity: From monogenic causes to polygenic risk.Reviews in endocrine & metabolic disorders · 2026Review
- Genome-wide mapping of common and rare variant effects on adiposity across childhood.Nature genetics · 2026Article
- Hypothalamic obesity.Reviews in endocrine & metabolic disorders · 2026Review
- Single-Cell Transcriptome-Wide Mendelian Randomization and Colocalization Uncover Potential Immunocytes-Related Therapeutic Targets for Obesity.Journal of cellular and molecular medicine · 2026Article
- The exonic SNP rs11676272-C risk allele mediates diet-induced obesity and reduces enhancer activation.EMBO reports · 2026Article
- Management of Childhood Obesity.International journal of molecular sciences · 2026Review
- The genetics of obesity: aetiology, prevention and therapy.Nature metabolism · 2026Review
- CircadianiScience · 2026Article
- AnResearch square · 2026Article
- Prevalence, Characteristics, and Genetic Architecture of Avoidant/Restrictive Food Intake Phenotypes.JAMA pediatrics · 2026Article
- Latest Advances in Obesity Treatment by Regulating Adipocyte Thermogenesis.PPAR research · 2026Review
- The rs713586 risk variant dysregulates ADCY3 rather than DNAJC27, leading to obesity through ZFP42-TET1-mediated DNA methylation.EBioMedicine · 2026Article
- Transcriptome analysis reveals reduced lipid accumulation and mitochondrial metabolic remodeling in ADCY3-overexpressing adipocytes.Functional & integrative genomics · 2025Article
- Genetic Polymorphisms Associated with Obesity in Southeast Asian Populations: A Systematic Review without Meta-Analysis.The Malaysian journal of medical sciences : MJMS · 2025Review
- A Rare Case of Monogenic Obesity Due to a Novel Variant in theJournal of clinical research in pediatric endocrinology · 2025Article
- Special Issue "New Insights into Adipose Tissue Metabolic Function and Dysfunction, 3rd Edition".International journal of molecular sciences · 2025Article
- Unveiling genetic signatures of immune response in immune-related diseases through single-cell eQTL analysis across diverse conditions.Nature communications · 2025Article
- Article
- Sex difference in BAT thermogenesis depends on PGC-1α-mediated phospholipid synthesis in mice.Nature communications · 2025Article
- Unraveling the Genetic Architecture of Obesity: A Path to Personalized Medicine.Diagnostics (Basel, Switzerland) · 2025Review
48 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 11 institutions in 5 countries.
Sadia SaeedCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France.ORCID http://orcid.org/0000-0003-3144-7772
Amélie BonnefondCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France.
Filippo TamaniniDepartment of Genomics of Common Disease, Imperial College London, London, UK.
Muhammad Usman MirzaDepartment of Pharmaceutical and Pharmacological Sciences, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-9120-2414
Jaida ManzoorDepartment of Pediatric Endocrinology, Children's Hospital, Lahore, Pakistan.
Qasim M JanjuaCentre for Research in Molecular Medicine, University of Lahore, Lahore, Pakistan.ORCID http://orcid.org/0000-0001-7896-8802
Sadia M DinDepartment of Biological Sciences, Forman Christian College, Lahore, Pakistan.
Julien GaitanCNRS, Laboratory of Membrane Chemistry and Biology (CBMN), UMR 5248, Bordeaux, France.
Alexandra MilochauCNRS, Laboratory of Membrane Chemistry and Biology (CBMN), UMR 5248, Bordeaux, France.
Emmanuelle DurandCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France.
Emmanuel VaillantCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France.
Attiya HaseebDepartment of Biological Sciences, Forman Christian College, Lahore, Pakistan.
Franck De GraeveCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France.
Iandry RabeariveloCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France.
Olivier SandCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France.
Gurvan QueniatCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France.
Raphaël BoutryCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France.
Dina A SchottDepartment of Pediatrics, Zuyderland Hospital, Heerlen, The Netherlands.
Hina AyeshaDepartment of Pediatrics, Punjab Medical College, Faisalabad, Pakistan.
Muhammad AliDepartment of Pediatrics, Mayo Hospital, King Edward Medical University, Lahore, Pakistan.
Waqas I KhanChildren Hospital and Institute of Child Health, Multan, Pakistan.
Taeed A ButtDepartment of Pediatrics, Fatima Memorial Hospital, Lahore, Pakistan.
Tuula RinneDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4350-8106
Connie StumpelDepartment of Clinical Genetics and GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
Amar AbderrahmaniCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France.
Jochen LangCNRS, Laboratory of Membrane Chemistry and Biology (CBMN), UMR 5248, Bordeaux, France.ORCID http://orcid.org/0000-0001-6847-5641
Muhammad ArslanCentre for Research in Molecular Medicine, University of Lahore, Lahore, Pakistan.
Philippe FroguelCentre National de la Recherche Scientifique (CNRS) UMR 8199, Institut Pasteur de Lille, University of Lille, Lille, France. p.froguel@imperial.ac.uk.ORCID http://orcid.org/0000-0003-2972-0784
Centre National de la Recherche Scientifique · FRForman Christian College · PKUniversity of Lahore · PKGenomics England · GBKing Edward Medical University · PKMaastricht University · NLMayo Hospital · PKPunjab Medical College · PKRadboud University Nijmegen · NLRega Institute for Medical Research · BEZuyderland Medisch Centrum · NL
Funding
No grant is acknowledged in the PubMed record.
Abstract
Study of monogenic forms of obesity has demonstrated the pivotal role of the central leptin-melanocortin pathway in controlling energy balance, appetite and body weight
Indexed as
Loss of Function MutationAdenylyl CyclasesAdolescentAnimalsCase-Control StudiesCells, CulturedChildCohort StudiesConsanguinityCricetinaeEnergy MetabolismFemaleGene FrequencyGenetic Predisposition to DiseaseHomozygoteHumansadenylate cyclase 3Adenylyl Cyclases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.