Evidence map›Paper›PMID 29311610›Full record

ArticleNature communications2018

Interneuron-specific signaling evokes distinctive somatostatin-mediated responses in adult cortical astrocytes.

Letizia Mariotti, Gabriele Losi, Annamaria Lia, Marcello Melone, Angela Chiavegato, Marta Gómez-Gonzalo, Michele Sessolo, Serena Bovetti, Angelo Forli, Micaela Zonta and 8 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 131 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. GABA-independent activation of GABANature communications · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Letizia MariottiNeuroscience Institute, National Research Council (CNR), 35121, Padova, Italy.
Gabriele LosiNeuroscience Institute, National Research Council (CNR), 35121, Padova, Italy.
Annamaria LiaNeuroscience Institute, National Research Council (CNR), 35121, Padova, Italy.
Marcello MeloneDepartment of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126, Ancona, Italy.
Angela ChiavegatoDepartment of Biomedical Sciences, Università degli Studi di Padova, 35121, Padova, Italy.
Marta Gómez-GonzaloNeuroscience Institute, National Research Council (CNR), 35121, Padova, Italy.
Michele SessoloNeuroscience Institute, National Research Council (CNR), 35121, Padova, Italy.
Serena BovettiOptical Approches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, 16163, Genova, Italy.
Angelo ForliOptical Approches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, 16163, Genova, Italy.
Micaela ZontaNeuroscience Institute, National Research Council (CNR), 35121, Padova, Italy.
Linda Maria RequieNeuroscience Institute, National Research Council (CNR), 35121, Padova, Italy.
Iacopo MarconNeuroscience Institute, National Research Council (CNR), 35121, Padova, Italy.
Arianna PuglieseDepartment of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126, Ancona, Italy.
Cécile ViolletInserm UMR894, Center for Psychiatry and Neuroscience, Université Paris-Descartes, 75014, Paris, France.
Bernhard BettlerDepartement of Biomedicine, University of Basel, 4031, Basel, Switzerland.
Tommaso FellinOptical Approches to Brain Function Laboratory, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, 16163, Genova, Italy.ORCID http://orcid.org/0000-0003-2718-7533
Fiorenzo ContiDepartment of Experimental and Clinical Medicine, Università Politecnica delle Marche, 60126, Ancona, Italy.
Giorgio CarmignotoNeuroscience Institute, National Research Council (CNR), 35121, Padova, Italy. giorgio.carmignoto@bio.unipd.it.ORCID http://orcid.org/0000-0003-3063-6774
University of Padua · ITItalian Institute of Technology · ITMarche Polytechnic University · ITInserm · FRUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional imaging in the adult mouse neocortex, we here reveal that parvalbumin- and somatostatin-expressing interneurons, two key interneuron classes in the brain, differentially signal to astrocytes inducing weak and robust GABA

Indexed as

Signal TransductionAnimalsAstrocytesCalciumInterneuronsMiceMice, Inbred C57BLMice, TransgenicNeocortexNeuronal PlasticityOptogeneticsParvalbuminsPatch-Clamp TechniquesReceptors, GABA-BSomatosensory CortexSomatostatinCalciumParvalbuminsReceptors, GABA-BSomatostatin

Identifiers

PMID29311610
PMCPMC5758790
OpenAlexW2782315930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.