Evidence map›Paper›PMID 29311566›Full record

ArticleNature communications2018

Multi-day rhythms modulate seizure risk in epilepsy.

Maxime O Baud, Jonathan K Kleen, Emily A Mirro, Jason C Andrechak, David King-Stephens, Edward F Chang, Vikram R Rao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 276 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
276citing papers in PubMed, 2 pooled it
38.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

276 citing papers in PubMed, 2 syntheses or guidelines pooled it, 548 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026
    Review
  11. Review
  12. Article
  13. Clusters in Thalamic iEEG Spectral Features Reveal Sleep/Wake Differences Over Time.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026
    Article
  14. Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

216 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Maxime O BaudDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, 94143, USA. maxime.baud.neuro@gmail.com.
Jonathan K KleenDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, 94143, USA.
Emily A MirroNeuroPace, Inc., 455N. Bernardo Ave, Mountain View, CA, 94043, USA.
Jason C AndrechakDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, 19716, USA.ORCID http://orcid.org/0000-0002-6659-9488
David King-StephensDepartment of Neurology, California Pacific Medical Center, San Francisco, CA, 94115, USA.
Edward F ChangDepartment of Neurological Surgery and Weill Institute for Neurosciences, University of California, San Francisco, CA, 94143, USA.
Vikram R RaoDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, 94143, USA.
University of California, San Francisco · USCalifornia Pacific Medical Center · USNeuroPace (United States) · USUniversity of Delaware · US

Funding

Functional organization of the superior temporal gyrus for speech perceptionR01DC012379 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Edward Chang · 2012 to 2026
$8.3M
NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)R25NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSEPHSON, SCOTT ANDREW · 2010 to 2023
$6.8M
NIDCD NIH HHS R01 DC012379NINDS NIH HHS R25 NS070680
6 · The paper itself

Abstract

Epilepsy is defined by the seemingly random occurrence of spontaneous seizures. The ability to anticipate seizures would enable preventative treatment strategies. A central but unresolved question concerns the relationship of seizure timing to fluctuating rates of interictal epileptiform discharges (here termed interictal epileptiform activity, IEA), a marker of brain irritability observed between seizures by electroencephalography (EEG). Here, in 37 subjects with an implanted brain stimulation device that detects IEA and seizures over years, we find that IEA oscillates with circadian and subject-specific multidien (multi-day) periods. Multidien periodicities, most commonly 20-30 days in duration, are robust and relatively stable for up to 10 years in men and women. We show that seizures occur preferentially during the rising phase of multidien IEA rhythms. Combining phase information from circadian and multidien IEA rhythms provides a novel biomarker for determining relative seizure risk with a large effect size in most subjects.

Indexed as

Circadian RhythmAdultElectric StimulationElectroencephalographyEpilepsyFemaleHumansMaleMiddle Aged

Identifiers

PMID29311566
PMCPMC5758806
OpenAlexW2782520840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.