ArticleScientific reports2018
Spontaneous and training-induced cortical plasticity in MD patients: Hints from lateral masking.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05904444 (The Effect of Duration Between Sessions on Microperimetric Biofeedback Training in Patients With Maculopathies), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Duration Between Sessions on Microperimetric Biofeedback Training in Patients With Maculopathies
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Perceptual Learning as a Rehabilitation Approach to Enhance Motion Processing in Maculopathy Patients.Investigative ophthalmology & visual science · 2026Article
- Extending Treatment Duration in Perceptual Learning for Amblyopia.Ophthalmology science · 2026Article
- Motion Processing in Visual Cortex of Maculopathy Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Characterization of contrast-mediated collinear interactions in the human visual system.Scientific reports · 2025Article
- The effect of duration between sessions on microperimetric biofeedback training in patients with maculopathies.Scientific reports · 2024Article
- Perceptual Learning Based on the Lateral Masking Paradigm in Anisometropic Amblyopia With or Without a Patching History.Translational vision science & technology · 2024Article
- tRNS boosts visual perceptual learning in participants with bilateral macular degeneration.Frontiers in aging neuroscience · 2024Article
- Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration.Translational vision science & technology · 2023Article
- Training With Simulated Scotoma Leads to Behavioral Improvements Through at Least Two Distinct Mechanisms.Investigative ophthalmology & visual science · 2023Article
- Optic Flow Processing in Patients With Macular Degeneration.Investigative ophthalmology & visual science · 2022Article
- Visuo-Acoustic Stimulation's Role in Synaptic Plasticity: A Review of the Literature.International journal of molecular sciences · 2021Review
- Perspective on Vision Science-Informed Interventions for Central Vision Loss.Frontiers in neuroscience · 2021Article
- Combining fixation and lateral masking training enhances perceptual learning effects in patients with macular degeneration.Journal of vision · 2020Article
- Anodal transcranial direct current stimulation reduces collinear lateral inhibition in normal peripheral vision.PloS one · 2020Article
- Contextual influences in the peripheral retina of patients with macular degeneration.Scientific reports · 2019Article
- Cortical Reorganization of Peripheral Vision Induced by Simulated Central Vision Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macular degeneration (MD) affects central vision and represents the leading cause of visual diseases in elderly population worldwide. As a consequence of central vision loss, MD patients develop a preferred retinal locus (PRL), an eccentric fixation point that replaces the fovea. Here, our aim was to determine whether and to what extent spontaneous plasticity takes place in the cortical regions formerly responding to central vision and whether a visual training based on perceptual learning (PL) can boost this plasticity within the PRL area. Spontaneous and PL-induced cortical plasticity were characterized by using lateral masking, a contrast sensitivity modulation induced by collinear flankers. This configuration is known to be sensitive to neural plasticity and underlies several rehabilitation trainings. Results in a group of 4 MD patients showed that collinear facilitation was similar to what observed in age- and eccentricity-matched controls. However, MD patients exhibited significantly reduced collinear inhibition, a sign of neural plasticity, consistent with the hypothesis of partial cortical reorganization. Three AMD patients from the same group showed a further reduction of inhibition after training, but not controls. This result suggests that PL might further boost neural plasticity, opening promising perspectives for the development of rehabilitation protocols for MD patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.