Evidence map›Paper›PMID 29311343›Full record

ReviewCold Spring Harbor perspectives in biology2018

The Interplay between the RNA Decay and Translation Machinery in Eukaryotes.

Adam M Heck, Jeffrey Wilusz

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Genome-wide mapping of DCP2-dependent 5' cap footprints inNAR genomics and bioinformatics · 2026
    Article
  2. RAN Translation-Coupled Decay of theInternational journal of molecular sciences · 2026
    Article
  3. Article
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  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. A Genetic Circuit Design for Targeted Viral RNA Degradation.Bioengineering (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Adam M HeckDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80525.
Jeffrey WiluszDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80525.

Funding

Flavivirus non-coding RNAs and the Host mRNA Decay MachineryR01AI123136 · NIAID · COLORADO STATE UNIVERSITY · PI WILUSZ, JEFFREY · 2016 to 2020
$1.9M
Pathological Implications of Repression of Cellular RNA Decay by Zika VirusR21AI130497 · NIAID · COLORADO STATE UNIVERSITY · PI WILUSZ, JEFFREY · 2017 to 2018
$408k
NIAID NIH HHS R01 AI123136NIAID NIH HHS R21 AI130497
6 · The paper itself

Abstract

RNA decay plays a major role in regulating gene expression and is tightly networked with other aspects of gene expression to effectively coordinate post-transcriptional regulation. The goal of this work is to provide an overview of the major factors and pathways of general messenger RNA (mRNA) decay in eukaryotic cells, and then discuss the effective interplay of this cytoplasmic process with the protein synthesis machinery. Given the transcript-specific and fluid nature of mRNA stability in response to changing cellular conditions, understanding the fundamental networking between RNA decay and translation will provide a foundation for a complete mechanistic understanding of this important aspect of cell biology.

Indexed as

Models, GeneticProtein BiosynthesisRNA StabilityEukaryotaGene Expression RegulationRNA, MessengerRNA, Messenger

Identifiers

PMID29311343
PMCPMC5932591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.