ArticleProceedings of the National Academy of Sciences of the United States of America2018
Melanopsin- and L-cone-induced pupil constriction is inhibited by S- and M-cones in humans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 84 citations in OpenAlex.
- Trial
- Simulated and natural changes in intraocular transparency selectively affect photoreceptor-specific pupil responses.Scientific reports · 2026Article
- Binocular combination in the autonomic nervous system.PloS one · 2026Article
- Cone-Specific Filter-Based Neuromodulation: A Proposed Clinical Framework for Amblyopia, Strabismus, and ADHD.Clinics and practice · 2025Article
- Lack of strong evidence for cone photoreceptors' contribution to human melatonin suppression and alerting response to light.iScience · 2025Article
- Article
- The Impact of Pupil Constriction on the Relationship Between Melanopic EDI and Melatonin Suppression in Young Adult Males.Journal of biological rhythms · 2024Article
- Regulation of pupil size in natural vision across the human lifespan.Royal Society open science · 2024Article
- Effects of calibrated blue-yellow changes in light on the human circadian clock.Nature human behaviour · 2024Article
- Integrative Lighting Aimed at Patients with Psychiatric and Neurological Disorders.Clocks & sleep · 2023Article
- Human-Centric Lighting Research and Policy in the Melanopsin Age.Policy insights from the behavioral and brain sciences · 2023Article
- Colour opponency is widespread across the mouse subcortical visual system and differentially targets GABAergic and non-GABAergic neurons.Scientific reports · 2023Article
- Circadian rhythm entrainment of the jewel wasp,Proceedings. Biological sciences · 2023Article
- Optogenetic restoration of high sensitivity vision with bReaChES, a red-shifted channelrhodopsin.Scientific reports · 2022Article
- Encoding the Photoreceptors of the Human Eye.Cureus · 2022Review
- Electroretinographic responses to luminance and cone-isolating white noise stimuli in macaques.Frontiers in neuroscience · 2022Article
- Comparison of macaque and human L- and M-cone driven electroretinograms.Experimental eye research · 2021Article
- Deep learning-based pupil model predicts time and spectral dependent light responses.Scientific reports · 2021Article
- The Effect of Refractive Error on Melanopsin-Driven Pupillary Responses.Investigative ophthalmology & visual science · 2020Article
- Prediction accuracy of L- and M-cone based human pupil light models.Scientific reports · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human retina contains five photoreceptor types: rods; short (S)-, mid (M)-, and long (L)-wavelength-sensitive cones; and melanopsin-expressing ganglion cells. Recently, it has been shown that selective increments in M-cone activation are paradoxically perceived as brightness decrements, as opposed to L-cone increments. Here we show that similar effects are also observed in the pupillary light response, whereby M-cone or S-cone increments lead to pupil dilation whereas L-cone or melanopic illuminance increments resulted in pupil constriction. Additionally, intermittent photoreceptor activation increased pupil constriction over a 30-min interval. Modulation of L-cone or melanopic illuminance within the 0.25-4-Hz frequency range resulted in more sustained pupillary constriction than light of constant intensity. Opposite results were found for S-cone and M-cone modulations (2 Hz), mirroring the dichotomy observed in the transient responses. The transient and sustained pupillary light responses therefore suggest that S- and M-cones provide inhibitory input to the pupillary control system when selectively activated, whereas L-cones and melanopsin response fulfill an excitatory role. These findings provide insight into functional networks in the human retina and the effect of color-coding in nonvisual responses to light, and imply that nonvisual and visual brightness discrimination may share a common pathway that starts in the retina.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.