ArticleProceedings of the National Academy of Sciences of the United States of America2018
Pyruvate induces torpor in obese mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Using Organoids to Unlock the Potential of Human Torpor for Spaceflight.Current stem cell reports · 2026Article
- Low dose systemic AAV-exendin-4 gene therapy for Prader-Willi syndrome and dietary obesity.Molecular therapy. Advances · 2026Article
- Effects of pyruvate administration on mRNA expression of inflammatory cytokines in adipose tissue and whole-body glucose metabolism in male mice.Physiological reports · 2025Article
- Tracking Hyperpolarized [1-NMR in biomedicine · 2025Article
- In vivo techniques for assessment of insulin sensitivity and glucose metabolism.The Journal of endocrinology · 2024Review
- Multiple time points of transcriptome analysis revealed altered genes involved in maintaining hibernation in the hypothalamus ofFrontiers in neuroscience · 2024Article
- Multi-sample/multi-nucleus parallel polarization and monitoring enabled by a fluid path technology compatible cryogenic probe for dissolution dynamic nuclear polarization.Scientific reports · 2023Article
- Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound.Nature metabolism · 2023Article
- Adenosine and P1 receptors: Key targets in the regulation of sleep, torpor, and hibernation.Frontiers in pharmacology · 2023Review
- HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury.JCI insight · 2022Article
- Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP-Epac-CREB Signaling Pathway.International journal of molecular sciences · 2022Article
- Obesity in male volcano miceFrontiers in nutrition · 2022Article
- A Dual Electrode Biosensor for Glucose and Lactate Measurement in Normal and Prolonged Obese Mice Using Single Drop of Whole Blood.Biosensors · 2021Article
- Obese Animals as Models for Numerous Diseases: Advantages and Applications.Medicina (Kaunas, Lithuania) · 2021Article
- Trans-omic analysis reveals obesity-associated dysregulation of inter-organ metabolic cycles between the liver and skeletal muscle.iScience · 2021Article
- Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer's disease.Brain, behavior, and immunity · 2020Article
- Impaired glucose tolerance, glucagon, and insulin responses in mice lacking the loop diuretic-sensitiveAmerican journal of physiology. Cell physiology · 2019Article
- Brown and Brite: The Fat Soldiers in the Anti-obesity Fight.Frontiers in physiology · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Mice subjected to cold or caloric deprivation can reduce body temperature and metabolic rate and enter a state of torpor. Here we show that administration of pyruvate, an energy-rich metabolic intermediate, can induce torpor in mice with diet-induced or genetic obesity. This is associated with marked hypothermia, decreased activity, and decreased metabolic rate. The drop in body temperature correlates with the degree of obesity and is blunted by housing mice at thermoneutrality. Induction of torpor by pyruvate in obese mice relies on adenosine signaling and is accompanied by changes in brain levels of hexose bisphosphate and GABA as detected by mass spectroscopy-based imaging. Pyruvate does not induce torpor in lean mice but results in the activation of brown adipose tissue (BAT) with an increase in the level of uncoupling protein-1 (UCP1). Denervation of BAT in lean mice blocks this increase in UCP1 and allows the pyruvate-induced torpor phenotype. Thus, pyruvate administration induces torpor in obese mice by pathways involving adenosine and GABA signaling and a failure of normal activation of BAT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.