ArticleProceedings of the National Academy of Sciences of the United States of America2018
IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
What it found
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Who cites it
31 citing papers in PubMed, 40 citations in OpenAlex.
- The IKKα-regulated microRNA miR-9-5p mediates lung cancer growth and invasiveness via CDH1/Wnt/β-catenin signalling.Cell death discovery · 2026Article
- The roles of IKKα in normal physiology and cancer.Cell communication and signaling : CCS · 2026Review
- Association of thymoquinone-induced changes in PINK1, DRP1, TFEB, and cytochrome c expression with mitochondrial dynamics and apoptosis in HepG2 and HDF cells.Medical oncology (Northwood, London, England) · 2025Article
- Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1.Nature communications · 2025Article
- Double trouble: cytosolic and nuclear IKKα in cancer.Open biology · 2025Review
- Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways.Molecular cancer · 2025Review
- Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans.Nature communications · 2024Article
- Targeting ROS production through inhibition of NADPH oxidases.Nature chemical biology · 2023Article
- TNFR1 and TNFR2, Which Link NF-κB Activation, Drive Lung Cancer Progression, Cell Dedifferentiation, and Metastasis.Cancers · 2023Review
- The Contribution of Oxidative Stress toAntioxidants (Basel, Switzerland) · 2023Review
- IKKα promotes lung adenocarcinoma growth through ERK signaling activation via DARPP-32-mediated inhibition of PP1 activity.NPJ precision oncology · 2023Article
- HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1.Cell death & disease · 2023Article
- NAC, NAC, Knockin' on Heaven's door: Interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells.Redox biology · 2022Review
- A TNFR1-UBCH10 axis drives lung squamous cell carcinoma dedifferentiation and metastasis through a cell-autonomous signaling loop.Cell death & disease · 2022Article
- Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer.British journal of cancer · 2022Article
- Direct Contact with Platelets Induces Podoplanin Expression and Invasion in Human Oral Squamous Cell Carcinoma Cells.Biomolecules & therapeutics · 2022Article
- Lysosomal inhibition sensitizes TMEM16A-expressing cancer cells to chemotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- IKKα-deficient lung adenocarcinomas generate an immunosuppressive microenvironment by overproducing Treg-inducing cytokines.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- NLRP3 Inhibition Ameliorates Severe Cutaneous Autoimmune Manifestations in a Mouse Model of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-Like Disease.The Journal of investigative dermatology · 2021Article
- Review
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Na-Young SongCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Feng ZhuCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Zining WangState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
Jami Willette-BrownCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Sichuan XiThoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Zhonghe SunLaboratory of Molecular Technology, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
Ling SuLaboratory of Molecular Technology, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
Xiaolin WuLaboratory of Molecular Technology, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
Buyong MaCancer and Inflammation Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
Ruth NussinovCancer and Inflammation Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702.
Xiaojun XiaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
David S SchrumpThoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Peter F JohnsonMouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702.
Michael KarinDepartment of Pharmacology, University of California, San Diego, La Jolla, CA 92093 Karinoffice@UCSD.edu huy2@mail.nih.gov.
Yinling HuCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702; Karinoffice@UCSD.edu huy2@mail.nih.gov.ORCID 0000-0002-4795-8537
Leidos (United States) · USNational Institutes of Health · USNational Cancer Institute · USSun Yat-sen University · CNUniversity of California San Diego · US
Funding
Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MEpigenetic Mechanisms of Gene Expression in Thoracic MalignanciesZIABC011115 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHRUMP, DAVID · 2009 to 2025
$15.1MProtein Structure, Stability, and Amyloid FormationZIABC010440 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NUSSINOV, RUTH · 2009 to 2025
$11.8MFunctions of IKK&945; in Skin Homeostasis and Skin TumorigenesisZIABC011212 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HU, YINLING · 2009 to 2025
$11.0MRole of IKK alpha in lung squamous cell carcinoma developmentZIABC011391 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HU, YINLING · 2011 to 2025
$9.1MIKKalpha, autophagy, obesity and injury enhanced pancreatic cancerR01CA163798 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARIN, MICHAEL · 2012 to 2016
$1.9MCCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC011212Intramural NIH HHS ZIA BC011391NCI NIH HHS HHSN261200800001ENCI NIH HHS R01 CA163798NIEHS NIH HHS P42 ES010337
Abstract
Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two distinct and predominant types of human lung cancer. IκB kinase α (IKKα) has been shown to suppress lung SCC development, but its role in ADC is unknown. We found inactivating mutations and homologous or hemizygous deletions in the
Indexed as
AcetophenonesAcetylcysteineAdenocarcinomaAnimalsCell ProliferationCellular SenescenceCyclin-Dependent Kinase Inhibitor p21Epigenesis, GeneticHumansI-kappa B KinaseLung NeoplasmsMiceNADPH Oxidase 2NF-E2-Related Factor 2Proto-Oncogene Proteins p21(ras)Reactive Oxygen SpeciesAcetophenonesacetovanilloneAcetylcysteineCHUK protein, humanChuk protein, mouseCybb protein, mouseCyclin-Dependent Kinase Inhibitor p21Hras protein, mouseI-kappa B KinaseNADPH Oxidase 2Nfe2l2 protein, mouseNF-E2-Related Factor 2Proto-Oncogene Proteins p21(ras)Reactive Oxygen SpeciesTumor Suppressor Protein p53cell senescenceIKKαlung adenocarcinomaROStumor progression
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.