Evidence map›Paper›PMID 29311258›Full record

ArticleThe Journal of biological chemistry2018

Molecular mechanisms of cutis laxa- and distal renal tubular acidosis-causing mutations in V-ATPase

Sally Esmail, Norbert Kartner, Yeqi Yao, Joo Wan Kim, Reinhart A F Reithmeier, Morris F Manolson

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Histone deacetylase-mediated regulation of endolysosomal pH.The Journal of biological chemistry · 2018
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Aberrant Expressions ofCurrent genomics · 2023
    Article
  7. Research progress on renal calculus associate with inborn error of metabolism.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. The Pathogenic Mechanism of theClinical, cosmetic and investigational dermatology · 2022
    Article
  12. The V-ATPaseInternational journal of molecular sciences · 2021
    Review
  13. Variants inBrain communications · 2021
    Article
  14. Regulation and function of V-ATPases in physiology and disease.Biochimica et biophysica acta. Biomembranes · 2020
    Review
  15. Article
  16. Article
  17. Distal renal tubular acidosis: genetic causes and management.World journal of pediatrics : WJP · 2019
    Review
  18. Article
  19. Vacuolar-type ATPase: A proton pump to lysosomal trafficking.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sally EsmailDental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6.
Norbert KartnerDental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6.
Yeqi YaoDental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6.
Joo Wan KimDental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6.
Reinhart A F ReithmeierDepartment of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Morris F ManolsonDental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address: m.manolson@utoronto.ca.
University of Toronto · CA

Funding

CIHR MOP-12333CIHR PJT-148508
6 · The paper itself

Abstract

The

Indexed as

Models, MolecularMutation, MissenseProtein Processing, Post-TranslationalAcidosis, Renal TubularAmino Acid SubstitutionCell MembraneCutis LaxaEndoplasmic ReticulumEnzyme StabilityGlycosylationGolgi ApparatusHEK293 CellsHumansKidneyProteasome Endopeptidase ComplexProtein Interaction Domains and MotifsATP6V0A2 protein, humanATP6V0A4 protein, humanATP6V1B1 protein, humanProteasome Endopeptidase ComplexProton-Translocating ATPasesRecombinant Fusion ProteinsVacuolar Proton-Translocating ATPasesVMA21 protein, human3D modelingATPaseER-associated degradationmembrane proteinN-glycosylationprotein degradationproton pumptrafficking

Identifiers

PMID29311258
PMCPMC5827428
OpenAlexW2783276331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.