ArticleHypertension (Dallas, Tex. : 1979)2018
Genetic and Environmental Effects on Gene Expression Signatures of Blood Pressure: A Transcriptome-Wide Twin Study.
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Article in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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21citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2020Pooled it
- Genetic Regulation of DNA Methylation and Its Mediating Role in Blood Pressure: A Genome-Wide Twin Study.MedComm · 2026Article
- Revealing genetic foundations underlying cardiometabolic traits: integrating twin and GWAS data in Asian populations.International journal of obesity (2005) · 2026Article
- Biological age acceleration in primary aldosteronism: associations with renin, aldosterone, aldosterone-to-renin ratio, and left ventricular mass index.Journal of hypertension · 2026Article
- CMGC Kinases in Viral Infection and Human Disease.Pathogens (Basel, Switzerland) · 2026Review
- Longitudinal changes in the genetic and environmental influences on DNA methylation linked to obesity measures: a 5-year twin study.Molecular biomedicine · 2025Article
- Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design.Cell & bioscience · 2025Article
- Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability.Journal of proteome research · 2025Article
- Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol-Related Sociomedical Conditions.Addiction biology · 2025Article
- Research trends in microRNA profiling as a biomarker for lung adenocarcinoma via liquid biopsy: A bibliometric analysis.Narra J · 2025Review
- Epigenomics and transcriptomics association study of blood pressure and incident diagnosis of hypertension in twins.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Trends of genetic contributions on epigenetic clocks and related methylation sites with aging: A population-based adult twin study.Aging cell · 2025Article
- MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Downregulation of mapk/mak/mrk overlapping kinase 1 in peripheral blood mononuclear cells of pediatric patients with type 1 diabetes mellitus.Journal of medical biochemistry · 2022Article
- Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values.Omics : a journal of integrative biology · 2022Article
- Article
- Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.Journal of the American Heart Association · 2021Article
- Bivariate genome-wide association study (GWAS) of body mass index and blood pressure phenotypes in northern Chinese twins.PloS one · 2021Article
- RNA Sequencing of Peripheral Blood Revealed that the Neurotropic TRK Receptor Signaling Pathway Shows Apparent Correlation in Recovery Following Spinal Cord Injury at Small Cohort.Journal of molecular neuroscience : MN · 2019Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Yisong HuangFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
Miina OllikainenFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
Pyry SipiläFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
Linda MustelinFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
Xin WangFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
Shaoyong SuFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
Tianxiao HuanFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
Daniel LevyFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
James WilsonFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
Harold SniederFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
Jaakko KaprioFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.).
Xiaoling WangFrom the Georgia Prevention Institution, Department of Population Health Sciences, Augusta University (Y.H., X.W., S.S., X.W.); Institute for Molecular Medicine Finland (M.O., J.K.) and Department of Public Health (P.S., L.M., J.K.), University of Helsinki; The National Heart, Lung, and Blood Institute's Framingham Heart Study, MA (T.H., D.L.); The Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, MD (T.H., D.L.); The Mississippi Center for Clinical and Translational Research (CCTR), The University of Mississippi Medical Center (J.W.); and Department of Epidemiology, University Medical Center Groningen, University of Groningen, the Netherlands (H.S.). xwang@augusta.edu.
National Heart Lung and Blood Institute · USInstitute for Molecular Medicine Finland · FIPrevention Institute · USUniversity of Helsinki · FIUniversity of Mississippi Medical Center · US
Funding
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1MTracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GRANGER, JOEY P. · 2016 to 2025
$38.2MA GENOME-WIDE METHYLATION STUDY ON ESSENTIAL HYPERTENSIONR01HL104125 · NHLBI · AUGUSTA UNIVERSITY · PI WANG, XIAOLING · 2011 to 2015
$2.9MNHLBI NIH HHS R01 HL104125NIGMS NIH HHS U54 GM115428
Abstract
Recently, 2 transcriptome-wide studies identified 40 genes that were differentially expressed in relation to blood pressure. However, to what extent these BP-related gene expression signatures and their associations with BP are driven by genetic or environmental factors has not been investigated. In this study of 391 twins (193 twin pairs and 5 singletons; age 55-69 years; 40% male; 57% monozygous) recruited from the Finnish Twin Cohort, transcriptome-wide data on peripheral leukocytes were obtained using the Illumina HT12 V4 array. Our transcriptome-wide analysis identified 1 gene (
Indexed as
Gene Expression RegulationSurveys and QuestionnairesAgedAnalysis of VarianceBlood PressureBlood Pressure DeterminationCohort StudiesEnvironmentFemaleFinlandGenome-Wide Association StudyHumansLinear ModelsMaleMiddle AgedReference Valuesadultblood pressuregene expressiontranscriptometwin study
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