Evidence map›Paper›PMID 29311239›Full record

ArticleInfection and immunity2018

Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling.

Bikash Sahay, Kathleen Bashant, Nicole L J Nelson, Rebeca L Patsey, Shiva Kumar Gadila, Rebecca Boohaker, Ashutosh Verma, Klemen Strle, Timothy J Sellati

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Strain-specific immune response patterns toInfection and immunity · 2026
    Article
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  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Bikash SahayCenter for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA sahayb@ufl.edu tsellati@southernresearch.org.
Kathleen BashantCenter for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA.
Nicole L J NelsonCenter for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA.
Rebeca L PatseyCenter for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA.
Shiva Kumar GadilaDepartment of Infectious Diseases, Drug Discovery Division, Southern Research, Birmingham, Alabama, USA.
Rebecca BoohakerDepartment of Infectious Diseases, Drug Discovery Division, Southern Research, Birmingham, Alabama, USA.
Ashutosh VermaTrudeau Institute, Saranac Lake, New York, USA.
Klemen StrleCenter for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Timothy J SellatiCenter for Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA sahayb@ufl.edu tsellati@southernresearch.org.
Albany Medical Center Hospital · USSouthern Research Institute · USMassachusetts General Hospital · USTrudeau Institute · USUniversity of Florida · US

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
CD14 AND THE IMMUNOPATHOGENESIS OF CHRONIC LYME DISEASER01AI054546 · NIAID · ALBANY MEDICAL COLLEGE · PI SELLATI, TIMOTHY J · 2004 to 2008
$1.7M
Defining Microbial and Host Factors in Innate Immune Responses in Lyme ArthritisK01AR062098 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI STRLE, KLEMEN · 2012 to 2014
$398k
NCI NIH HHS P30 CA013148NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI054546NIAMS NIH HHS K01 AR062098
6 · The paper itself

Abstract

Host genotype influences the severity of murine Lyme borreliosis, caused by the spirochetal bacterium

Indexed as

Chromatin Assembly and DisassemblyAnimalsArthritisBorrelia burgdorferiCyclic AMPCytokinesGene Expression ProfilingInterleukin-10Lipopolysaccharide ReceptorsLyme DiseaseMacrophagesMiceMonocytesp38 Mitogen-Activated Protein KinasesPromoter Regions, GeneticSp1 Transcription FactorCyclic AMPCytokinesInterleukin-10Lipopolysaccharide Receptorsp38 Mitogen-Activated Protein KinasesSp1 Transcription FactorSTAT3 Transcription FactorBorreliaIL-10Lymemacrophages

Identifiers

PMID29311239
PMCPMC5865024
OpenAlexW2782833479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.