Evidence map›Paper›PMID 29311237›Full record

ArticleInfection and immunity2018

Evaluation of CpxRA as a Therapeutic Target for Uropathogenic Escherichia coli Infections.

Lana Dbeibo, Julia J van Rensburg, Sara N Smith, Kate R Fortney, Dharanesh Gangaiah, Hongyu Gao, Juan Marzoa, Yunlong Liu, Harry L T Mobley, Stanley M Spinola

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Anti-infective compounds forSustainable microbiology · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Cpx-signalling innpj antimicrobials and resistance · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Nutrient Limitation SensitizesACS infectious diseases · 2023
    Article
  15. Article
  16. The Small Non-coding RNAJournal of veterinary research · 2023
    Article
  17. Article
  18. Article
  19. "Omics" Technologies - What Have They Told Us About UropathogenicFrontiers in cellular and infection microbiology · 2022
    Review
  20. Role ofFrontiers in microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Lana DbeiboDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Julia J van RensburgDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Sara N SmithDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Kate R FortneyDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Dharanesh GangaiahDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hongyu GaoDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Juan MarzoaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Yunlong LiuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Harry L T MobleyDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Stanley M SpinolaDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA sspinola@iu.edu.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineUniversity of Michigan–Ann Arbor · USUniversidade de Santiago de Compostela · ES

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Reciprocal Control of Motility and Adherence in UTIR01AI059722 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PEARSON, MELANIE M. · 2005 to 2024
$7.4M
E. coli virulence gene expression during clinical UTIs in womenR01DK094777 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOBLEY, HARRY L. · 2011 to 2019
$3.6M
Vaccine to prevent E. coli urinary tract infectionR01AI116791 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOBLEY, HARRY L. · 2016 to 2020
$2.0M
NCATS NIH HHS UL1 TR001108NIAID NIH HHS R01 AI059722NIAID NIH HHS R01 AI116791NIDDK NIH HHS R01 DK094777
6 · The paper itself

Abstract

CpxRA is an envelope stress response system found in all members of the family

Indexed as

AnimalsBacterial ProteinsEscherichia coli InfectionsEscherichia coli ProteinsFemaleGene Expression Regulation, BacterialHumansMiceMice, Inbred CBAMutationProtein KinasesUrinary Tract InfectionsUropathogenic Escherichia coliVirulence FactorsBacterial ProteinsCpxA protein, E coliCpxR protein, BacteriaEscherichia coli ProteinsProtein KinasesVirulence FactorsantivirulencecpxAcpxRcpxRAEscherichia coliUPECuropathogenicvirulence determinants

Identifiers

PMID29311237
PMCPMC5820967
OpenAlexW2783463403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.