ArticleAnnals of family medicine2018
Detecting Hepatitis B and C by Combined Public Health and Primary Care Birth Cohort Testing.
Article in Annals of family medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Effect of a Community-Based Hepatitis B Virus Infection Detection Combined with Vaccination Program in China.Vaccines · 2021Article
- Estimating regional prevalence of chronic hepatitis C with a capture-recapture analysis.BMC infectious diseases · 2021Article
- A Cross-Sectional Study Comparing Two Opt-Out HIV Testing Strategies in the Out-Patient Setting.Frontiers in public health · 2021Article
- Chronic hepatitis B and C infections in the Netherlands: estimated prevalence in risk groups and the general population.Epidemiology and infection · 2019Article
- Strategies for achieving viral hepatitis C micro-elimination in the Netherlands.Hepatology, medicine and policy · 2018Review
- Unravelling the Hidden and Undiagnosed Cases of Hepatitis B and C Viruses among Patients Seeking Health Care for Other Viral Illness: A Cross-Sectional Study from Central India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBoth chronic hepatitis C (HCV) and B virus (HBV) infections are generally asymptomatic, and many remain undetected or are diagnosed at a late stage. Studies that evaluate best practice hepatitis testing strategies are needed to better detect this hidden population.
methodsIn this prospective cohort study, we aimed to determine the diagnostic yield (test uptake and rate of positive test results) of a combined public health and primary care birth cohort testing strategy in detecting hidden cases of HCV and HBV infections. We invited all patients aged between 40 and 70 years (n = 6,743) registered with 11 family practices serving 2 higher prevalence areas, or hotspots (ie, estimated HCV prevalence of 1%; national estimated prevalence is 0.1-0.4%), in the south of the Netherlands.
resultsTest uptake was 50.9% (n = 3,434 patients). No active or chronic HCV infection was detected: 0.00% (95% CI, 0.00%-0.11%). Positive test rates were 0.20% (95% CI, 0.08%-0.42%) for anti-HCV (n = 7), 0.26% (95% CI, 0.12%-0.50%) for hepatitis B surface antigen (n = 9), and 4.14% (95% CI, 3.49%-4.86%) for antihepatitis B core (n = 142).
conclusionsThis best practice testing strategy was effective in achieving a high test uptake. It completely failed, however, to detect hidden chronic HCV infections and is not recommended for countries with a low prevalence of the disease.
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