Evidence map›Paper›PMID 29311144›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Differentiation and Characterization of Excitatory and Inhibitory Synapses by Cryo-electron Tomography and Correlative Microscopy.

Chang-Lu Tao, Yun-Tao Liu, Rong Sun, Bin Zhang, Lei Qi, Sakar Shivakoti, Chong-Li Tian, Peijun Zhang, Pak-Ming Lau, Z Hong Zhou and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 211 citations in OpenAlex.

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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Chang-Lu TaoNational Laboratory for Physical Sciences at the Microscale.ORCID 0000-0003-0236-7239
Yun-Tao LiuNational Laboratory for Physical Sciences at the Microscale.ORCID 0000-0003-2577-1859
Rong SunNational Laboratory for Physical Sciences at the Microscale.
Bin ZhangChinese Academy of Sciences Key Laboratory of Brain Function and Disease.
Lei QiChinese Academy of Sciences Key Laboratory of Brain Function and Disease.
Sakar ShivakotiNational Laboratory for Physical Sciences at the Microscale.
Chong-Li TianChinese Academy of Sciences Key Laboratory of Brain Function and Disease.
Peijun ZhangDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX37BN, United Kingdom.ORCID 0000-0003-1803-691X
Pak-Ming LauChinese Academy of Sciences Key Laboratory of Brain Function and Disease.
Z Hong ZhouNational Laboratory for Physical Sciences at the Microscale, gqbi@ustc.edu.cn hong.zhou@ucla.edu.ORCID 0000-0002-8373-4717
Guo-Qiang BiNational Laboratory for Physical Sciences at the Microscale, gqbi@ustc.edu.cn hong.zhou@ucla.edu.ORCID 0000-0001-8735-3818
Chinese Academy of Sciences · CNMicroscale (United States) · USCalifornia NanoSystems Institute · USCentre for Human Genetics · GBUniversity of Science and Technology of China · CN

Funding

High-Resolution CryoEM Reconstruction of Large ComplexesR01GM071940 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHOU, Z HONG · 2006 to 2025
$5.0M
HIGH-END CRYOEM INSTRUMENT FOR UCLA ELECTRON IMAGING CTR FOR NANOMACHINES: AIDSS10RR023057 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2006 to 2006
$1.6M
Direct Detection Device for atomic resolution cryoEM of macromolecular complexesS10OD018111 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHOU, Z HONG · 2014 to 2014
$598k
NCRR NIH HHS S10 RR023057NIGMS NIH HHS R01 GM071940NIH HHS S10 OD018111Wellcome Trust 206422/Z/17/Z
6 · The paper itself

Abstract

As key functional units in neural circuits, different types of neuronal synapses play distinct roles in brain information processing, learning, and memory. Synaptic abnormalities are believed to underlie various neurological and psychiatric disorders. Here, by combining cryo-electron tomography and cryo-correlative light and electron microscopy, we distinguished intact excitatory and inhibitory synapses of cultured hippocampal neurons, and visualized the

Indexed as

Inhibition, PsychologicalAnimalsCell Adhesion MoleculesCryoelectron MicroscopyExcitatory Postsynaptic PotentialsFemaleImage Processing, Computer-AssistedNeuronsPost-Synaptic DensityPregnancyRatsReceptors, GABA-AReceptors, GlutamateSynapsesSynaptic VesiclesTomographyCell Adhesion MoleculesReceptors, GABA-AReceptors, Glutamatecorrelative light and electron microscopycryo-electron tomographyneurotransmitter receptorpostsynaptic densitysynaptic ultrastructuresynaptic vesicle

Identifiers

PMID29311144
PMCPMC5815350
OpenAlexW2783481291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.